Abstract
The major function of the voltage-gated calcium channels is to provide the Ca2+ flux into the cell. L-type voltage-gated calcium channels (Cav1) serve as voltage sensors that couple membrane depolarization to many intracellular processes. Electrical activity in excitable cells affects gene expression through signaling pathways involved in the excitation-transcription (E-T) coupling. E-T coupling starts with activation of the Cav1 channel and results in initiation of the cAMP-response element binding protein (CREB)-dependent transcription. In this review we discuss the new quantitative approaches to measuring E-T signaling events. We describe the use of wavelet transform to detect heterogeneity of transcriptional activation in nuclei. Furthermore, we discuss the properties of discovered microdomains of nuclear signaling associated with the E-T coupling and the basis of the frequency-dependent transcriptional regulation.
Keywords: Image analysis, microdomain, signaling, transcription, voltage-gated calcium channels, wavelet.
Graphical Abstract
Current Molecular Pharmacology
Title:Heterogeneity of Calcium Channel/cAMP-Dependent Transcriptional Activation
Volume: 8
Author(s): Evgeny Kobrinsky
Affiliation:
Keywords: Image analysis, microdomain, signaling, transcription, voltage-gated calcium channels, wavelet.
Abstract: The major function of the voltage-gated calcium channels is to provide the Ca2+ flux into the cell. L-type voltage-gated calcium channels (Cav1) serve as voltage sensors that couple membrane depolarization to many intracellular processes. Electrical activity in excitable cells affects gene expression through signaling pathways involved in the excitation-transcription (E-T) coupling. E-T coupling starts with activation of the Cav1 channel and results in initiation of the cAMP-response element binding protein (CREB)-dependent transcription. In this review we discuss the new quantitative approaches to measuring E-T signaling events. We describe the use of wavelet transform to detect heterogeneity of transcriptional activation in nuclei. Furthermore, we discuss the properties of discovered microdomains of nuclear signaling associated with the E-T coupling and the basis of the frequency-dependent transcriptional regulation.
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Cite this article as:
Kobrinsky Evgeny, Heterogeneity of Calcium Channel/cAMP-Dependent Transcriptional Activation, Current Molecular Pharmacology 2015; 8 (1) . https://dx.doi.org/10.2174/1874467208666150507093601
DOI https://dx.doi.org/10.2174/1874467208666150507093601 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
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