摘要
流行病学的研究为长期暴露在比较低含量镉中(如今发生在工业化国家)可能会造成健康危险提供了越来越多的证据。因此,人们关注有效防治暴露于重金属而带来的负面效应的兴趣日益增长。因为大量镉的毒性作用影响源于它的促氧化性能,似乎特殊的关注应该指向能预防或减少金属引发抗氧化应激的原因和它在组织,器官或者系统中的毒性风险是合理的(包括肝脏、肾脏、睾丸、耳朵、眼睛、心血管系统、神经系统和骨骼系统)。这篇综述讨论了表现出抗镉毒性作用的大范围自然(源于植物和动物)和合成抗氧化剂和许多植物浸膏(如红茶和绿茶、黑果腺肋花楸、大蒜、洋葱、罗勒油、海枣、灯笼果、姜)。而且,一些关注集中于一些没有抗氧化潜能的物质可能也能阻止镉诱发的抗氧化应激这一事实和它的结果。到目前为止,关于自然和合成抗氧化剂的保护作用和植物浸膏的数据来源于动物模型研究。然而,其中大量的抗氧化剂或浸膏可能有希望成为人体镉毒性的预防/治疗方针。进一步研究因环境或职业引起的暴露于镉的抗氧化剂预防和治疗用法是必要的,而这些有毒金属的有效治疗螯合疗法是目前所缺乏的。
关键词: 抗氧化剂,生命元素,镉,相互作用,抗氧化应激,植物浸膏,保护作用,维他命
图形摘要
Current Drug Targets
Title:Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium
Volume: 17 Issue: 12
Author(s): Malgorzata M. Brzóska, Sylwia Borowska, Michal Tomczyk
Affiliation:
关键词: 抗氧化剂,生命元素,镉,相互作用,抗氧化应激,植物浸膏,保护作用,维他命
摘要: Epidemiological studies provide a growing number of evidences that chronic exposure to relatively low levels of cadmium (Cd), nowadays taking place in industrialized countries, may cause health hazard. Thus, growing interest has been focused on effective ways of protection from adverse effects of exposure to this heavy metal. Because numerous effects to Cd’s toxic action result from its prooxidative properties, it seems reasonable that special attention should be directed to agents that can prevent or reduce this metal-induced oxidative stress and its consequences in tissues, organs and systems at risk of toxicity, including liver, kidneys, testes, ears, eyes, cardiovascular system and nervous system as well as bone tissue. This review discusses a wide range of natural (plant and animal origin) and synthetic antioxidants together with many plant extracts (e.g. black and green tea, Aronia melanocarpa, Allium sativum, Allium cepa, Ocimum sanctum, Phoenix dactylifera, Physalis peruviana, Zingiber officinale) that have been shown to prevent from Cd toxicity. Moreover, some attention has been focused on the fact that substances not possessing antioxidative potential may also prevent Cd-induced oxidative stress and its consequences. So far, most of the data on the protective effects of the natural and synthetic antioxidants and plant extracts come from studies in animals’ models; however, numerous of them seem to be promising preventive/therapeutic strategies for Cd toxicity in humans. Further investigation of prophylactic and therapeutic use of antioxidants in populations exposed to Cd environmentally and occupationally is warranted, given that therapeutically effective chelation therapy for this toxic metal is currently lacking.
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Malgorzata M. Brzóska, Sylwia Borowska, Michal Tomczyk , Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium, Current Drug Targets 2016; 17 (12) . https://dx.doi.org/10.2174/1389450116666150506114336
DOI https://dx.doi.org/10.2174/1389450116666150506114336 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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