氧化还原反应相关机制重新平衡癌细胞生长失调

Title:Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth

Volume: 17 Issue: 12

Author(s): An-Sofie Stevens, Nicky Pirotte, Annelies Wouters, Andromeda Van Roten, Frank Van Belleghem, Maxime Willems, Ann Cuypers and Tom Artois and Karen Smeets

Affiliation:

关键词: 抗癌症治疗，癌变，氧化还原相关机制，再生，干细胞

摘要: A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells.

Cite this article as:

An-Sofie Stevens, Nicky Pirotte, Annelies Wouters, Andromeda Van Roten, Frank Van Belleghem, Maxime Willems, Ann Cuypers and Tom Artois and Karen Smeets , Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth, Current Drug Targets 2016; 17 (12) . https://dx.doi.org/10.2174/1389450116666150506112817