Abstract
Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]¯ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.
Keywords: Carbonyl compounds, catalysis, ionic liquids, Knoevenagel condensation, olefins.
Graphical Abstract
Current Organic Synthesis
Title:A Simple and Efficient Procedure for Knoevenagel Reaction Promoted by Imidazolium-Based Ionic Liquids
Volume: 13 Issue: 1
Author(s): Xiaomei Hu, Conelius Ngwa and Qinguo Zheng
Affiliation:
Keywords: Carbonyl compounds, catalysis, ionic liquids, Knoevenagel condensation, olefins.
Abstract: Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]¯ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.
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Cite this article as:
Hu Xiaomei, Ngwa Conelius and Zheng Qinguo, A Simple and Efficient Procedure for Knoevenagel Reaction Promoted by Imidazolium-Based Ionic Liquids, Current Organic Synthesis 2016; 13 (1) . https://dx.doi.org/10.2174/1570179412666150505185134
DOI https://dx.doi.org/10.2174/1570179412666150505185134 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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