摘要
宫颈癌是第二大致命的癌症,具有很高的发病率和死亡率。在发展中国家,常规治疗策略如外科手术、放化疗并没有得到广泛使用。为了促使药物传递至病变部位,从而减少全身副作用,目前癌症研究的重点是使用各种方法,如基因治疗、光热治疗和利用纳米粒子、水凝胶、脂质体输送系统或以多种形式存在的系统如阴道环、阴道内斑块和阴道片等传递系统传递化疗药物来治疗宫颈癌。本文讨论了用于治疗宫颈癌的现有的不同输送系统和方法。
关键词: 血管生成,宫颈癌,输送系统,药物靶标,人乳头瘤病毒,肿瘤。
图形摘要
Current Drug Targets
Title:Current Perspectives on Novel Drug Delivery Systems and Approaches for Management of Cervical Cancer: A Comprehensive Review
Volume: 17 Issue: 3
Author(s): Umme Hani, Riyaz Ali M. Osmani, Rohit R. Bhosale, Hosakote Gurumallappa Shivakumar and Parthasarathi K. Kulkarni
Affiliation:
关键词: 血管生成,宫颈癌,输送系统,药物靶标,人乳头瘤病毒,肿瘤。
摘要: Cervical cancer is uterine cervix carcinoma, the second deadly cancer and has a high incidence and mortality rate. In the developing world conventional treatment strategies such as surgical intervention and chemoradiotherapy are less widely available. Currently cancer research focuses on improving treatment of cervical cancer using various therapies such as gene therapy, recombinant protein therapy, photodynamic therapy, photothermal therapy and delivery of chemotherapeutic agents using nanoparticles, hydrogel and liposomal based delivery systems and also localized delivery systems which exist in a variety of forms such as intravaginal rings, intravaginal patches, intravaginal films, etc. in order to improve the drug delivery in a controlled manner to the diseased site thereby reducing systemic side effects. The present review encloses existing diverse delivery systems and approaches intended for treatment of cervical cancer.
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Cite this article as:
Umme Hani, Riyaz Ali M. Osmani, Rohit R. Bhosale, Hosakote Gurumallappa Shivakumar and Parthasarathi K. Kulkarni , Current Perspectives on Novel Drug Delivery Systems and Approaches for Management of Cervical Cancer: A Comprehensive Review, Current Drug Targets 2016; 17 (3) . https://dx.doi.org/10.2174/1389450116666150505154720
DOI https://dx.doi.org/10.2174/1389450116666150505154720 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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