不对称姜黄素类似物作为治疗阿尔茨海默氏病的潜在性多功能制剂的合成和评估

Title:Syntheses and Evaluation of Asymmetric Curcumin Analogues as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease

Volume: 12 Issue: 5

Author(s): Peng Zhai, Chun-Li Xia, Jia-Heng Tan, Ding Li, Tian-Miao Ou, Shi-Liang Huang, Lian-Quan Gu and Zhi-Shu Huang

Affiliation:

关键词: β-淀粉样蛋白聚合物；防治阿尔茨海默氏病制剂；姜黄素类似物；金属离子螯合；多功能缓蚀剂

摘要: A series of new asymmetric curcumin analogues were synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer’s disease. Our results showed that most of these synthetic compounds had better inhibitory properties against Aβ aggregation compared with curcumin, and better anti-oxidative properties compared with the reference compound Trolox through the study of oxygen radical absorbance capacity (ORAC). Some compounds showed good properties in selectively chelating metal ions such as copper and iron. Besides, some compounds were found to be able to dissociate Aβ protein which had already aggregated. The structure-activity relationships (SAR) of these synthetic compounds were studied. The present investigation indicated that our synthetic asymmetric curcumin derivatives could be potential multifunctional agents for the treatment of Alzheimer’s disease (AD).

Cite this article as:

Peng Zhai, Chun-Li Xia, Jia-Heng Tan, Ding Li, Tian-Miao Ou, Shi-Liang Huang, Lian-Quan Gu and Zhi-Shu Huang , Syntheses and Evaluation of Asymmetric Curcumin Analogues as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease, Current Alzheimer Research 2015; 12 (5) . https://dx.doi.org/10.2174/1567205012666150504151120