The LPS-Pretreated MSCs Supply a Positive Microenvironment for Tumor Cell Proliferation and Clone Formation

Title:The LPS-Pretreated MSCs Supply a Positive Microenvironment for Tumor Cell Proliferation and Clone Formation

Volume: 16 Issue: 4

Author(s): Pengfei Li, Jin Liu, Junzhong Sun and Haifeng Duan

Affiliation:

Keywords: Inflammatory cytokine, LPS, MSC, tumor growth.

Abstract: In this study, the culture supernatant of LPS-treated MSCs was collected and served as a conditioned medium (CM). It was found that the LPS-CM promoted the proliferation of tumor cells (SKBR3, MDA-MB-231, A549, 95D and HepG2). In addition, the colony formation ability was also enhanced by LPS-CM incubation. The inflammatory cytokines, IL-6 and IL-8, were demonstrated to be up-regulated in the LPS-CM, which we supposed to function in the tumor-growth promotion in vitro.

Cite this article as:

Li Pengfei, Liu Jin, Sun Junzhong and Duan Haifeng, The LPS-Pretreated MSCs Supply a Positive Microenvironment for Tumor Cell Proliferation and Clone Formation, Current Protein & Peptide Science 2015; 16 (4) . https://dx.doi.org/10.2174/138920371604150429152720

DOI https://dx.doi.org/10.2174/138920371604150429152720	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550