Molecular Pockets, Umbrellas and Quasi Podands from Steroids: Synthesis, Structure and Applications

Title:Molecular Pockets, Umbrellas and Quasi Podands from Steroids: Synthesis, Structure and Applications

Volume: 12 Issue: 3

Author(s): Tomasz Pospieszny

Affiliation:

Keywords: Bile acids, molecular pockets, molecular umbrellas, PASS, PM5, quasi podands, sterols.

Abstract: A new methods for the synthesis of molecular pockets, molecular umbrellas as well as quasi podands of steroids derivatives have been described. Moreover, a molecular umbrellas and pockets derived from biogenic precursors and their applications are described. Intermolecular 1,3- dipolar cycloaddition gave a quasi podands with 1,2,3-triazole rings. The structures of the products were confirmed by spectral analysis, mass spectrometry and PM5 semiempirical methods. Estimation of the pharmacotherapeutic potential of synthesized compounds has been accomplished on the basis of Prediction of Activity Spectra for Substances (PASS).

Cite this article as:

Pospieszny Tomasz, Molecular Pockets, Umbrellas and Quasi Podands from Steroids: Synthesis, Structure and Applications, Mini-Reviews in Organic Chemistry 2015; 12 (3) . https://dx.doi.org/10.2174/1570193X1203150429105154