Abstract
The skin presents several advantages as an administration route, including the possibility of localizing drugs in the tissue and overcoming the first-pass effect. However, its use is limited by the barrier function of the tissue, which is provided mainly (but not exclusively) by the stratum corneum. Various strategies to overcome this layer, have been considered over the years, ranging from the use of physical methods such as iontophoresis to wellknown conventional chemical penetration enhancers like oleic acid and DMSO. However, delivery of hydrophilic and large compounds remains a challenge. More recently, selected groups of peptides have attracted increasing attention due to their ability to penetrate into the skin promoting the transport of small and large molecules, including nanodispersed systems. Here, we will discuss the properties and application to cutaneous (into the skin) and transdermal (across the skin) delivery of three groups of peptides, namely protein-transduction domains, phagedisplayed peptides and antimicrobial peptides.
Keywords: Protein transduction domain, cell penetrating peptides, skin, transdermal delivery, topical.
Current Pharmaceutical Design
Title:Potential of Peptide-Based Enhancers for Transdermal Delivery
Volume: 21 Issue: 20
Author(s): Luciana B. Lopes, Vanessa F.M. Carvalho and Debora P. de Lemos
Affiliation:
Keywords: Protein transduction domain, cell penetrating peptides, skin, transdermal delivery, topical.
Abstract: The skin presents several advantages as an administration route, including the possibility of localizing drugs in the tissue and overcoming the first-pass effect. However, its use is limited by the barrier function of the tissue, which is provided mainly (but not exclusively) by the stratum corneum. Various strategies to overcome this layer, have been considered over the years, ranging from the use of physical methods such as iontophoresis to wellknown conventional chemical penetration enhancers like oleic acid and DMSO. However, delivery of hydrophilic and large compounds remains a challenge. More recently, selected groups of peptides have attracted increasing attention due to their ability to penetrate into the skin promoting the transport of small and large molecules, including nanodispersed systems. Here, we will discuss the properties and application to cutaneous (into the skin) and transdermal (across the skin) delivery of three groups of peptides, namely protein-transduction domains, phagedisplayed peptides and antimicrobial peptides.
Export Options
About this article
Cite this article as:
Lopes B. Luciana, Carvalho F.M. Vanessa and de Lemos P. Debora, Potential of Peptide-Based Enhancers for Transdermal Delivery, Current Pharmaceutical Design 2015; 21 (20) . https://dx.doi.org/10.2174/1381612821666150428143243
DOI https://dx.doi.org/10.2174/1381612821666150428143243 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Potential Benefits of Glitazones for Cancer and Vascular Disease
Current Drug Therapy Controversies in Glaucoma: Current Medical Treatment and Drug Development
Current Pharmaceutical Design Identification of Site(s) of Insulin Nitration by Peroxynitrite and Characterization of Its Structural Change
Protein & Peptide Letters Editorial [Hot Topic: The Endothelin System: Vascular Targets for Therapy in Disease (Guest Editor: Michael R. Dashwood)]
Current Vascular Pharmacology Circulating Levels of Uric Acid and Risk for Metabolic Syndrome
Current Diabetes Reviews Inhibition of Mitogen-Activated Protein Kinases (MAPKs) as a Strategy to Prevent Intimal Hyperplasia Following Cardiovascular Interventions
Vascular Disease Prevention (Discontinued) Diabetes Trends in Hospitalized HIV-Infected Persons in the United States, 1994-2004
Current HIV Research High Mobility Group Box 1 Protein as a Potential Drug Target for Infection- and Injury-Elicited Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Novel Leucine Rich Repeat Domains in Proteins from Unicellular Eukaryotes and Bacteria
Protein & Peptide Letters Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications
Current Alzheimer Research An Insight of Alpha-amylase Inhibitors as a Valuable Tool in the Management of Type 2 Diabetes Mellitus
Current Diabetes Reviews Recent Advances on the Antiatherogenic Effects of HDL-Derived Proteins and Mimetic Peptides
Current Pharmaceutical Design Editorial [ Special Issue on Atherosclerosis Executive Editors: Pedro R. Moreno, Javier Sanz and Valentin Fuster ]
Current Molecular Medicine Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome
Cardiovascular & Hematological Disorders-Drug Targets Muscarinic Acetylcholine Receptors: Relevance to Infertility and Male Contraception
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Comparison Between Computed Tomography Angiography and Digital Subtraction Angiography in Critical Lower Limb Ischemia
Current Medical Imaging Impact of Red Wine Consumption on Cardiovascular Health
Current Medicinal Chemistry Changes in the Density of Corneal Endothelial Cells in Elderly Diabetic Patients After Combined Phacovitrectomy and Ex-PRESS Glaucoma Implants
Current Pharmaceutical Biotechnology Nanoparticles as Novel Carrier for Brain Delivery: A Review
Current Pharmaceutical Design Combined Oral Contraceptive in Adolescent and Young Adult Women: Current Evidence and Future Perspectives
Current Women`s Health Reviews