Generic placeholder image

Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Nano Clinoptilolite: Highly Efficient Catalyst for the Synthesis of Chromene Derivatives Under Solvent-Free Conditions

Author(s): Sara Hallajian, Mohammad A. Khalilzadeh, Mahgol Tajbakhsh, Eskandar Alipour and Zahra Safaei

Volume 18, Issue 5, 2015

Page: [486 - 491] Pages: 6

DOI: 10.2174/1386207318666150424104452

Price: $65

Abstract

An efficient and selective synthesis of substituted chromene derivatives via threecomponent reaction of 4-hydroxycoumarin or 1,3-dicarbonyl compounds, activated acetylenic compounds and N-nucleophiles is described. The reaction was conducted under solvent-free conditions at 70°C using potassium fluoride impregnated on natural zeolite as a cheap and available solid base. The procedure has several advantages involving selectivity, excellent yields and a convenient work-up method.

Keywords: 4-hydroxycoumarin, acetylenic compounds, N-nucleophiles, solvent-free.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy