摘要
细菌型VI分泌系统 (T6SS)是革兰氏阴性菌与其他细菌和真核宿主细胞交互的工具。尽管近年来T6SS在细菌间交互中吸引了太多的注目,T6SS作为人类毒力因子的研究仍速度缓慢。然而,T6SS已显示出在几个水平上(从宿主细胞的直接攻击到疾病的减弱)干扰真核宿主细胞免疫,这允许病原体在宿主环境中存活的更久。本文旨在全面综述细菌在哺乳动物宿主细胞免疫调节中使用其T6SS的方式。与此同时,我们尝试描述潜在的研究新途径,以及概述T6SS以何种方式成为能够绕过现有抗生素耐药性的治疗靶标。尽管仍有许多工作有待完成,对T6SS作用机制更好的理解无疑会导致新策略来消除T6SS耐受病原体。
关键词: 细菌,效应器,免疫,感染,病原体,分泌,T6SS,毒力。
Current Medicinal Chemistry
Title:Role of the Bacterial Type VI Secretion System in the Modulation of Mammalian Host Cell Immunity
Volume: 22 Issue: 14
Author(s): Marlies De Ceuleneer, Martine Vanhoucke and Rudi Beyaert
Affiliation:
关键词: 细菌,效应器,免疫,感染,病原体,分泌,T6SS,毒力。
摘要: The type VI Secretion System (T6SS) is a tool for Gram-negative pathogens to interact with other bacteria as well as with the eukaryotic host cell. While the role of T6SS in interbacterial interactions has drawn much attention in recent years, research into the T6SS as a human virulence factor continues at a slower pace. Nevertheless, T6SS has been shown to interfere with eukaryotic host cell immunity at several levels, ranging from direct attack of the host cell to attenuation of disease, allowing the pathogen to survive longer in the host environment. In this review, we aim to give a comprehensive overview focused on the ways bacteria use their T6SS in the modulation of mammalian host cell immunity. While doing so, we attempt to describe potential new avenues of research, as well as outline the ways in which T6SS could become a therapeutic target allowing to circumvent existing antibiotic resistance. Although much work remains to be done, a better comprehension of the T6SS mechanisms of action will undoubtedly lead to new strategies to counteract T6SS-bearing pathogens.
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Marlies De Ceuleneer, Martine Vanhoucke and Rudi Beyaert , Role of the Bacterial Type VI Secretion System in the Modulation of Mammalian Host Cell Immunity, Current Medicinal Chemistry 2015; 22 (14) . https://dx.doi.org/10.2174/0929867322666150417123744
DOI https://dx.doi.org/10.2174/0929867322666150417123744 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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