摘要
非酒精性脂肪肝(NAFLD)不仅由于其患病率上升,更因为其缺乏可持续的治疗方案而成为是巨大的难题。肠道菌群被认为参与其发生和发展过程,因此,他们的控制作用被当作治疗目标研究。本文综述了肠道菌群对NAFLD发病机制的参与情况。此外,我们总结了旨在治疗NAFLD患者肠道微生态失调的最新的动物和人体实验研究结果。最后,我们综述了在治疗NAFLD时控制短链脂肪酸和胆汁酸信号的疗效的证据。
关键词: 胆汁酸,菌群失调,脂肪肝,肠道菌群,NAFLD,NASH。
图形摘要
Current Drug Targets
Title:Targeting the Gut Microbiota for the Treatment of Non-Alcoholic Fatty Liver Disease
Volume: 16 Issue: 12
Author(s): Marialena Mouzaki and Robert Bandsma
Affiliation:
关键词: 胆汁酸,菌群失调,脂肪肝,肠道菌群,NAFLD,NASH。
摘要: Non-alcoholic fatty liver disease (NAFLD) is a challenge not only due to its rising prevalence but also, and perhaps more importantly, due to the lack of sustainable treatment options. Intestinal microbiota are thought to participate in the development and progression of NAFLD and their manipulation is, hence, being investigated as a treatment aim. This review summarizes the involvement of intestinal microbiota in the pathogenesis on NAFLD. In addition, we synthesize the results of the most recent animal and human studies aimed at treating dysbiosis seen in patients with NAFLD. Lastly, we review the evidence regarding the efficacy of manipulating short chain fatty acid and bile acid signaling in the treatment of NAFLD.
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Cite this article as:
Marialena Mouzaki and Robert Bandsma , Targeting the Gut Microbiota for the Treatment of Non-Alcoholic Fatty Liver Disease, Current Drug Targets 2015; 16 (12) . https://dx.doi.org/10.2174/1389450116666150416120351
DOI https://dx.doi.org/10.2174/1389450116666150416120351 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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