对心脑血管疾病治疗的靶向给药

Title:Targeted Drug Delivery for Cardiovascular and Cerebrovascular Diseases

Volume: 17 Issue: 4

Author(s): Jingjing Luan and Guangxi Zhai

Affiliation:

关键词: 心脑血管疾病，病理生理改变，被动，主动，理化，靶向性，药物传递，载体。

摘要: Cardiovascular and cerebrovascular diseases (CCVD) are a major and increasing health burden worldwide. Although treatments have been made a certain progress, the development of novel therapies for patients remains a major research object. There are a lot of drugs against CCVD, but most of them lack tissue specificity with a short half-life, which seriously limits their extensive clinical application. Utilization of some pathophysiological changes caused by CCVD, targeted drug distribution in CCVD patients could be achieved. The current review aims to capture various drug delivery systems transporting drug specifically to vascular disease, including passive, active and physicochemical targeted delivery carriers. Their design strategies and mechanisms are described in detail. The present limitations and future perspective are also discussed.

Cite this article as:

Jingjing Luan and Guangxi Zhai , Targeted Drug Delivery for Cardiovascular and Cerebrovascular Diseases, Current Drug Targets 2016; 17 (4) . https://dx.doi.org/10.2174/1389450116666150416120224