药物靶点，miRNAs，破骨细胞，骨溶解疾病，骨稳态，生物发生。

Title:Doxorubicin Action on Mitochondria: Relevance to Osteosarcoma Therapy?

Volume: 19 Issue: 5

关键词: 阿霉素，线粒体，癌症，骨肉瘤，凋亡，骨骼。

摘要: Background: The mitochondria may very well determine the final commitment of the cell to death, particularly in times of energy stress. Cancer chemotherapeutics such as the anthracycline doxorubicin perturb mitochondrial structure and function in tumour cells, as evidenced in osteosarcoma, for which doxorubicin is used clinically as frontline therapy. This same mechanism of cell inhibition is also pertinent to doxorubicin’s primary cause of side-effects, that to the cardiac tissue, culminating in such dire events as congestive heart failure. Reactive oxygen species are partly to blame for this effect on the mitochondria, which impact the electron transport chain.

Objective: As this review highlights that, there is much more to be learnt about the mitochondria and how it is affected by such effective but toxic drugs as doxorubicin.

Conclusion: Such information will aid researchers who search for cancer treatment able to preserve mitochondrial number and function in normal cells.

Cite this article as:

Doxorubicin Action on Mitochondria: Relevance to Osteosarcoma Therapy?, Current Drug Targets 2018; 19 (5) . https://dx.doi.org/10.2174/1389450116666150416115852