摘要
目前,动脉粥样硬化被认为是由几类细胞及分子介导的慢性炎症疾病。细胞因子在动脉粥样硬化斑块微环境中引发和维持炎症的作用与相互作用的方式必须引起重视。细胞因子总是由所有涉及动脉粥样硬化发病机理有关的细胞表达的,它们作用于各种多效的靶点并主要负责内皮细胞、平滑肌细胞、白细胞及其它属于血管的细胞间的通讯。本文综述了目前讨论最多的细胞因子在动脉粥样硬化过程发挥作用的相关信息,并讨论这些细胞因子对于动脉粥样硬化和冠状动脉疾病的预后价值。
关键词: 动脉粥样硬化,细胞因子,冠状动脉疾病,白介素,预测价值
Current Medicinal Chemistry
Title:The Role and Predictive Value of Cytokines in Atherosclerosis and Coronary Artery Disease
Volume: 22 Issue: 22
Author(s): Dimitris Tousoulis, Evangelos K. Economou, Evangelos Oikonomou, Nikolaos Papageorgiou, Gerasimos Siasos, George Latsios, Eleni Kokkou, Kostantinos Mourouzis, Spyridon Papaioannou, Spyridon Deftereos, Michael W. Cleman, Maria Lymberi, Vasiliki Gennimata and Christodoulos Stefanadis
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关键词: 动脉粥样硬化,细胞因子,冠状动脉疾病,白介素,预测价值
摘要: Atherosclerosis is currently regarded as a chronic inflammatory disease that is mediated by several types of cells and molecules. Emphasis has been placed on the role of cytokines and the way they act and interact to initiate and sustain inflammation in the microenvironment of an atherosclerotic plaque. Cytokines are invariably expressed by all cells involved in the pathogenesis of atherosclerosis, act on a variety of targets exerting multiple effects and are largely responsible for the crosstalk among endothelial, smooth muscle cells, leukocytes and other vascular residing cells. In the present paper our aim is to review current information on the role of the most commonly discussed cytokines in the process of atherogenesis and to discuss the prognostic significance of these cytokines in atherosclerosis and coronary artery disease.
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Dimitris Tousoulis , Evangelos K. Economou , Evangelos Oikonomou , Nikolaos Papageorgiou , Gerasimos Siasos , George Latsios , Eleni Kokkou , Kostantinos Mourouzis , Spyridon Papaioannou , Spyridon Deftereos , Michael W. Cleman , Maria Lymberi , Vasiliki Gennimata and Christodoulos Stefanadis , The Role and Predictive Value of Cytokines in Atherosclerosis and Coronary Artery Disease, Current Medicinal Chemistry 2015; 22 (22) . https://dx.doi.org/10.2174/0929867322666150415145814
DOI https://dx.doi.org/10.2174/0929867322666150415145814 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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