Abstract
The rapidly expanding knowledge of the pathogenesis of a variety of forms of cancer at the molecular level is now providing new targets for drug discovery and development. This has enabled us to successfully develop rationally designed therapies for cancer patients, and the results of their clinical evaluation are now becoming available. The optimal clinical development of target-based anticancer drugs will require fundamental changes to the way trials are designed, outcome is evaluated, and patients are selected to receive therapy. A thorough knowledge of what is accomplished so far is the cornerstone to optimally develop and implement these new strategies.
Keywords: targeted therapy, egfr, her2, vegfr
Current Cancer Therapy Reviews
Title: Membrane Receptor and Antiangiogenic Targeted Therapies in the Treatment of Cancer
Volume: 1 Issue: 1
Author(s): Antonio Jimeno and Hernán Cortes-Funes
Affiliation:
Keywords: targeted therapy, egfr, her2, vegfr
Abstract: The rapidly expanding knowledge of the pathogenesis of a variety of forms of cancer at the molecular level is now providing new targets for drug discovery and development. This has enabled us to successfully develop rationally designed therapies for cancer patients, and the results of their clinical evaluation are now becoming available. The optimal clinical development of target-based anticancer drugs will require fundamental changes to the way trials are designed, outcome is evaluated, and patients are selected to receive therapy. A thorough knowledge of what is accomplished so far is the cornerstone to optimally develop and implement these new strategies.
Export Options
About this article
Cite this article as:
Jimeno Antonio and Cortes-Funes Hernán, Membrane Receptor and Antiangiogenic Targeted Therapies in the Treatment of Cancer, Current Cancer Therapy Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573394052952519
DOI https://dx.doi.org/10.2174/1573394052952519 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Development of New Drugs for COPD
Current Medicinal Chemistry Sirtuins: Multifaceted Drug Targets
Current Molecular Medicine Ellagic Acid: Cytodifferentiating and Antiproliferative Effects In Human Prostatic Cancer Cell Lines
Current Pharmaceutical Design Novel Mechanistic Insights into the Anti-cancer Mode of Arsenic Trioxide
Current Cancer Drug Targets Myeloproliferative Neoplasms Including Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis, Chronic Neutrophilic Leukemia, and Myeloproliferative Neoplasm, Unclassifiable
Current Cancer Therapy Reviews Tumor Specific Novel Taxoid-Monoclonal Antibody Conjugates
Current Medicinal Chemistry Potential Advantages of Using Synchrotron X-ray Based Techniques in Pediatric Research
Current Medicinal Chemistry High Expression of Human Leukocyte Antigen-G is Associated with a Poor Prognosis in Patients with PDAC
Current Molecular Medicine Preclinical Models of Graves’ Disease and Associated Secondary Complications
Current Pharmaceutical Design Effect of Cytostatic Drugs on the mRNA Expression Levels of Ribonuclease κ in Breast and Ovarian Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Androgen Receptor Cofactors in Prostate Cancer: Potential Therapeutic Targets of Castration-Resistant Prostate Cancer
Current Cancer Drug Targets The Function of the Selective Inhibitors of Cycloxygenase 2
Mini-Reviews in Medicinal Chemistry Interstitial Lung Disease in Sjogrens Syndrome
Current Rheumatology Reviews The JNK Signaling Pathway Is a Novel Molecular Target for S-Propargyl- L-Cysteine, a Naturally-Occurring Garlic Derivatives: Link to Its Anticancer Activity in Pancreatic Cancer In Vitro and In Vivo
Current Cancer Drug Targets Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives
Anti-Cancer Agents in Medicinal Chemistry Leukocyte-Independent Effects of CC-Chemokines on Vascular Remodeling
Current Pharmaceutical Biotechnology CFTR Gene Transfer to Lung Epithelium - On the Trail of a Target Cell
Current Gene Therapy Preparation, Characterization and in vivo Evaluation of Raloxifene Hydrochloride Solid Lipid Nanoparticles
Pharmaceutical Nanotechnology Human Carboxylesterases: An Update on CES1, CES2 and CES3
Protein & Peptide Letters Lifelong Endocrine Fluctuations and Related Cognitive Disorders
Current Pharmaceutical Design