Abstract
A DBU-catalyzed one-pot multicomponent reaction involving indane-1,3-dione, aldehydes, and 1,4-dithiane-2,5-diol for the synthesis of spirocyclic tetrahydrothiophene derivatives has been developed. A series of spirocyclic tetrahydrothiophene derivatives were obtained in generally good to excellent yields with high diastereoselectivity via this synthetic strategy. Importantly, this methodology has several advantages, such as mild reaction conditions, broad scope of substrates, easy operations and so on.
Keywords: Aldehydes, DBU, 1, 4-dithiane-2, 5-diol, indane-1, 3-dione, multi-component reaction, one-pot, organocatalysis, tetrahydrothiophene.
Current Organocatalysis
Title:DBU-Catalyzed One-Pot Multicomponent Reaction for the Synthesis of Spirocyclic Tetrahydrothiophene Derivatives
Volume: 3 Issue: 2
Author(s): Jindian Duan, Jing Cheng and Pengfei Li
Affiliation:
Keywords: Aldehydes, DBU, 1, 4-dithiane-2, 5-diol, indane-1, 3-dione, multi-component reaction, one-pot, organocatalysis, tetrahydrothiophene.
Abstract: A DBU-catalyzed one-pot multicomponent reaction involving indane-1,3-dione, aldehydes, and 1,4-dithiane-2,5-diol for the synthesis of spirocyclic tetrahydrothiophene derivatives has been developed. A series of spirocyclic tetrahydrothiophene derivatives were obtained in generally good to excellent yields with high diastereoselectivity via this synthetic strategy. Importantly, this methodology has several advantages, such as mild reaction conditions, broad scope of substrates, easy operations and so on.
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Cite this article as:
Duan Jindian, Cheng Jing and Li Pengfei, DBU-Catalyzed One-Pot Multicomponent Reaction for the Synthesis of Spirocyclic Tetrahydrothiophene Derivatives, Current Organocatalysis 2016; 3 (2) . https://dx.doi.org/10.2174/2213337202666150414201456
DOI https://dx.doi.org/10.2174/2213337202666150414201456 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
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