摘要
结核病(TB)是由结核杆菌(MTB)感染引起,其再次出现成为世界公众的主要健康问题。多重耐药性MTB菌株数量的增加 和最近越来越多关于普遍抗耐药性菌株病原体的出现,大大削弱了抗TB的治疗策略,漫长且暴露了期对于病人的毒性及其他副作用。搜索新的抗TB药物基本包括现存非专利和FDA已经批准的有机药物的再利用,现存有机药物类似物的改性旨在缩短和改善药物对疾病的治疗,或者搜寻新的抗分支杆菌的的可能作用机制。通过不同靶点生化途径疗法设计的机会,无机药物化学为有机药物化学提供了替代选择。潜在药物分子结构与金属铁离子的配合物为药物化学家提供了探索结构多样性的机会,可以利用多种金属的氧化形态,并且也通过其与金属中心的配位,为增强已确定有机药物的活性提供可能性。本综述中我们概括了目前对金属配合物抗结核能力的了解,他们的作用机制并推测了关于他们的潜在临床应用。
关键词: 抗结核分枝杆菌活性,抗结核活性,无机药物化学,金属配合物,结核分枝杆菌
Current Medicinal Chemistry
Title:Tuberculosis: An Inorganic Medicinal Chemistry Perspective
Volume: 22 Issue: 18
Author(s): Livia Viganor, Ciaran Skerry, Malachy McCann and Michael Devereux
Affiliation:
关键词: 抗结核分枝杆菌活性,抗结核活性,无机药物化学,金属配合物,结核分枝杆菌
摘要: Tuberculosis (TB) which is caused by the resilient pathogen Mycobacterium tuberculosis (MTB) has re-emerged to become a leading public health problem in the world. The growing number of multi-drug resistant MTB strains and the more recently emerging problem with the extensively drug resistant strains of the pathogen are greatly undermining conventional anti-TB therapeutic strategies which are lengthy and expose patients to toxicity and other unwanted side effects. The search for new anti-TB drugs essentially involves either the repurposing of existing organic drugs which are now off patent and already FDA approved, the synthesis of modified analogues of existing organic drugs, with the aim of shortening and improving drug treatment for the disease, or the search for novel structures that offer the possibility of new mechanisms of action against the mycobacterium. Inorganic medicinal chemistry offers an alternative to organic drugs through opportunities for the design of therapeutics that target different biochemical pathways. The incorporation of metal ions into the molecular structure of a potential drug offers the medicinal chemist an opportunity to exploit structural diversity, have access to various oxidation states of the metal and also offer the possibility of enhancing the activity of an established organic drug through its coordination to the metal centre. In this review, we summarize what is currently known about the antitubercular capability of metal complexes, their mechanisms of action and speculate on their potential applications in the clinic.
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Cite this article as:
Livia Viganor, Ciaran Skerry, Malachy McCann and Michael Devereux , Tuberculosis: An Inorganic Medicinal Chemistry Perspective, Current Medicinal Chemistry 2015; 22 (18) . https://dx.doi.org/10.2174/0929867322666150408112357
DOI https://dx.doi.org/10.2174/0929867322666150408112357 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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