摘要
荧光标记葡萄糖探针提供了一种替代传统的、放射性的基于检测生物系统中的葡萄糖流量的方法。因此,设想这些探针将会被广泛应用。然而情况不是这样的,自从19世纪80年代中期他们的发展,荧光标记葡萄糖生物探针在生物研究中并未充分利用,与放射性方法相比,每年只有少数论文(<10)使用这些探针。然而,近5年其在研究科研方面激增。截止2012年,多数新颖探针被开发并且研究论文的数量也出现了可观的增长。这与癌症、神经病学和糖尿病研究的药物发现应用尤其相关。在这篇综述文章中,我们讨论了这些生物探针的学术影响力及评估了成功适用于药物发现应用的探针。值得注意的是,我们讨论了最新研究,其可以显示出被用于在动物模型和在基于体内药物验证应用方面的探针潜力。总之,我们希望这篇综述可以增我们对研究机遇的认识,这些探针有助于药物发现学术界。
关键词: 抗癌,抗糖尿病,药物筛选,药物批准,荧光标记葡萄糖探针,转基因
Current Medicinal Chemistry
Title:Sugars that Glow in the Dark: Fluorescent Tagged Glucose Bioprobes and their Facilitation of the Drug Discovery Process
Volume: 22 Issue: 15
Author(s): JungIn Um, JiHyung Lee, Da-Woon Jung and Darren R. Williams
Affiliation:
关键词: 抗癌,抗糖尿病,药物筛选,药物批准,荧光标记葡萄糖探针,转基因
摘要: Fluorescent tagged glucose probes offer an attractive alternative to traditional, radioactive based methods for measuring glucose flux in biological systems. Thus, it could be envisaged that these probes would be widely used. However, this is not the case and, since their development in the mid-1980s, fluorescent tagged glucose bioprobes are relatively underutilized in biological research compared to radioactive methods, with only a small number (<10) publications per year using these probes. However, within the past five years there has been a surge in research activity. By the year 2012, numerous novel probes were developed and the number of research publications dramatically increased. This was especially relevant for drug discovery applications related to cancer, neurology and diabetes research. In this review article, we discuss the research impact of these bioprobes and assess which probes have been most successfully applied to drug discovery applications. Significantly, we also discuss latest research that shows the potential of these probes to be used for drug discovery in animal models and their application to in vivo-based drug validation. Overall, we hope that this review will raise awareness of the research opportunities that these probes offer to the drug discovery research community.
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Cite this article as:
JungIn Um, JiHyung Lee, Da-Woon Jung and Darren R. Williams , Sugars that Glow in the Dark: Fluorescent Tagged Glucose Bioprobes and their Facilitation of the Drug Discovery Process, Current Medicinal Chemistry 2015; 22 (15) . https://dx.doi.org/10.2174/0929867322666150408111120
DOI https://dx.doi.org/10.2174/0929867322666150408111120 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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