摘要
非酒精性脂肪性肝病(NAFLD)的组织学特征为肝内脂滴异常积累,这是与胰岛素抵抗呈正相关关系。患有该疾病的病人可以发展为肝炎和肝硬化,例如非酒精脂肪性肝炎(NASH)。目前,非酒精性脂肪肝的发生机制尚不完全清楚。甘油三酯(TAG),主要存在于脂滴中,目前被认为是对抗非甘油三酯毒性脂滴种类积累的缓冲剂。近年来的研究表明,胰岛素抵抗是由肝细胞中的磷脂酸和甘油二酯所引起,胆固醇过载的星状细胞与肝纤维化有关。因此,为了阐明NASH的发病机制和寻找新的治疗靶点,识别导致NAFLD进展的有毒的脂质种类十分重要。 本文将脂质分为五类,即为脂肪酰基、甘油、甘油酯、鞘脂、和甾醇脂质,并描述了它们生理过程中的分子结构、分布和代谢,以及他们对NAFLD进展的促进作用。
关键词: 肝纤维化,肝炎,胰岛素抵抗,脂质合成,脂质运输,毒性脂质。
图形摘要
Current Drug Targets
Title:Identification of Lipid Species Linked to the Progression of Non-alcoholic Fatty Liver Disease
Volume: 16 Issue: 12
Author(s): Yuki Kawano, Shin Nishiumi, Masaya Saito, Yoshihiko Yano, Takeshi Azuma and Masaru Yoshida
Affiliation:
关键词: 肝纤维化,肝炎,胰岛素抵抗,脂质合成,脂质运输,毒性脂质。
摘要: Non-alcoholic fatty liver disease (NAFLD) is histologically characterized by the aberrant accumulation of lipid droplets in the liver, which is positively correlated with insulin resistance. Within the spectrum of this disease, patients can develop hepatitis and cirrhosis; i.e., non-alcoholic steatohepatitis (NASH). The mechanisms responsible for the progression of NAFLD are not fully understood. Triacylglycerol (TAG), which is mainly found in lipid droplets, is currently considered to act as a buffer against the accumulation of non-TAG toxic lipid species. In line with this, recent studies have revealed that insulin resistance is driven by the accumulation of phosphatidic acid and diacylglycerol in hepatocytes and that cholesterol-overloaded stellate cells are associated with fibrosis in the liver. Therefore, it is important to identify the toxic lipid species that contribute to NAFLD progression in order to clarify the pathogenesis of NASH and find novel targets for its treatment. In this review, we divided lipids into five classes; i.e., into fatty acyls, glycerophospholipids, glycerolipids, sphingolipids, and sterol lipids, and described their molecular structures, distributions, and metabolism under physiological conditions, as well as the contributions they make to the progression of NAFLD.
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Cite this article as:
Yuki Kawano, Shin Nishiumi, Masaya Saito, Yoshihiko Yano, Takeshi Azuma and Masaru Yoshida , Identification of Lipid Species Linked to the Progression of Non-alcoholic Fatty Liver Disease, Current Drug Targets 2015; 16 (12) . https://dx.doi.org/10.2174/1389450116666150408103318
DOI https://dx.doi.org/10.2174/1389450116666150408103318 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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