Novel Insights Into c-Src

Title: Novel Insights Into c-Src

Volume: 11 Issue: 9

Author(s): O. Alper and E. T. Bowden

Affiliation:

Keywords: c-src, v-src, tumorigenesis, angiogenesis, genomics

Abstract: Since identifying a transmissible agent responsible for tumorigenesis in chickens, the v-Src oncogene, significant progress has been made in determining the functions of its cellular homologue. c-Src is the product of the SRC gene and has been found both over-expressed and highly activated in a number of human cancers. In fact the relationship between c-Src activation and cancer progression is significant. Furthermore c-Src may play a role in the acquisition of the invasive and metastatic phenotype. In this review we will summarize some of the latest evidence for the role of c-Src in tumorigenesis and particularly in human tumor progression. In this review, specifically, we will address growth signals, adhesion, migration, invasion, angiogenesis and functional genomics.

Cite this article as:

Alper O. and Bowden T. E., Novel Insights Into c-Src, Current Pharmaceutical Design 2005; 11 (9) . https://dx.doi.org/10.2174/1381612053507576