摘要
传统癌症疗法是受到一些明显的障碍,包括低效率、阻力、全身并发症等。利用近红外(NIR)非侵入性和靶向检测金纳米结构是非常有吸引力的,由于其独特的物理化学性质在NIR光谱下有特别强的吸收、散射和高表面积体积比以及活泼的表面化学性质可以被操纵,以表面改性和官能化提高生物相容性。在本综述中,光热治疗(PTT)的进展以及靶向投递抗癌剂的金纳米结构的主要应用将详细地介绍,并且影像指导的治疗和操作参数优化将是重点。随近红外光控靶向给药和/或光热消融的金纳米结构治疗下的转移也进行了简要讨论。这些金纳米结构为开发更好的癌症治疗策略铺平了道路。
关键词: 癌症治疗,药物投递系统,金纳米结构,影像指导治疗,转移,近红外(NIR)光,光热治疗(PTT)
图形摘要
Current Cancer Drug Targets
Title:Near-infrared Light Activatable Multimodal Gold Nanostructures Platform: An Emerging Paradigm for Cancer Therapy
Volume: 15 Issue: 5
Author(s): Yaping Jiang, Wei Fei, Xiao Cen, Yaling Tang and Xinhua Liang
Affiliation:
关键词: 癌症治疗,药物投递系统,金纳米结构,影像指导治疗,转移,近红外(NIR)光,光热治疗(PTT)
摘要: Traditional therapy for cancer is subject to some evident obstacles, including low effectiveness, resistance, systemic complication, etc. Gold nanostructures responsive to near-infrared (NIR) light are attractive for non-invasive and targeted therapy because of their unique physical properties especially strong absorption and scattering, and high surface area-to-volume ratio as well as the ease of which their surface chemistry can be manipulated to enhance biocompatibility surface modification and functionalization. In this Review, the progress of photothermal therapy (PTT) as well as the targeted delivery of anticancer agents as the predominant applications of gold nanostructures is detailed, with a focus on imaging-guided therapy and optimizing operational parameters. The NIR light-controlled targeted delivery and/or photothermal ablation of gold nanostructures in the treatment of metastasis are also briefly discussed. These gold nanostructures pave the way for developing better therapeutic strategies of cancer.
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Cite this article as:
Yaping Jiang, Wei Fei, Xiao Cen, Yaling Tang and Xinhua Liang , Near-infrared Light Activatable Multimodal Gold Nanostructures Platform: An Emerging Paradigm for Cancer Therapy, Current Cancer Drug Targets 2015; 15 (5) . https://dx.doi.org/10.2174/1568009615666150407125333
DOI https://dx.doi.org/10.2174/1568009615666150407125333 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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