Title:Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems
Volume: 16
Issue: 6
Author(s): Dickson K. Kirui and Mauro Ferrari
Affiliation:
关键词:
生物屏障,药物投递,疗效,活体镜检,血管运输。
摘要: Rapid technical advances in the field of non-linear microscopy have made intravital microscopy
a vital pre-clinical tool for research and development of imaging-guided drug delivery systems.
The ability to dynamically monitor the fate of macromolecules in live animals provides invaluable information
regarding properties of drug carriers (size, charge, and surface coating), physiological, and
pathological processes that exist between point-of-injection and the projected of site of delivery, all of
which influence delivery and effectiveness of drug delivery systems. In this Review, we highlight how
integrating intravital microscopy imaging with experimental designs (in vitro analyses and mathematical modeling) can
provide unique information critical in the design of novel disease-relevant drug delivery platforms with improved diagnostic
and therapeutic indexes. The Review will provide the reader an overview of the various applications for which intravital
microscopy has been used to monitor the delivery of diagnostic and therapeutic agents and discuss some of their
potential clinical applications.