摘要
非线性显微领域快速得技术进步使活体显微镜检查成为成为一种重要的临床前工具,用于研究和发展影像引导药物投递系统。其对活体内大分子活动的动态监视能力能提供关于药物载体性能(尺寸,电荷,表面包膜)和 注射点与预计投递点之间的生理和病理过程的大量信息。上述性能和过程会影响药物投递和投递系统的效果。在这篇综述中,我们着重讲述了带有实验设计(体外分析和数学模型)的集成活体显微成像为什么能提供关于诊断和治疗指数更高的新颖疾病相关药物投递平台的关键的独特信息。这篇综述会给读者提供用于监视诊断和治疗药物的投递的活体镜检的各种应用的概述,还会讨论它们潜在的临床应用。
关键词: 生物屏障,药物投递,疗效,活体镜检,血管运输。
Current Drug Targets
Title:Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems
Volume: 16 Issue: 6
Author(s): Dickson K. Kirui and Mauro Ferrari
Affiliation:
关键词: 生物屏障,药物投递,疗效,活体镜检,血管运输。
摘要: Rapid technical advances in the field of non-linear microscopy have made intravital microscopy a vital pre-clinical tool for research and development of imaging-guided drug delivery systems. The ability to dynamically monitor the fate of macromolecules in live animals provides invaluable information regarding properties of drug carriers (size, charge, and surface coating), physiological, and pathological processes that exist between point-of-injection and the projected of site of delivery, all of which influence delivery and effectiveness of drug delivery systems. In this Review, we highlight how integrating intravital microscopy imaging with experimental designs (in vitro analyses and mathematical modeling) can provide unique information critical in the design of novel disease-relevant drug delivery platforms with improved diagnostic and therapeutic indexes. The Review will provide the reader an overview of the various applications for which intravital microscopy has been used to monitor the delivery of diagnostic and therapeutic agents and discuss some of their potential clinical applications.
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Cite this article as:
Dickson K. Kirui and Mauro Ferrari , Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems, Current Drug Targets 2015; 16 (6) . https://dx.doi.org/10.2174/1389450116666150330114030
DOI https://dx.doi.org/10.2174/1389450116666150330114030 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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