Antibacterial Properties of Tetraalkylammonium and Imidazolium Tetraalkoxycalix[4]arene Derivatives

Title:Antibacterial Properties of Tetraalkylammonium and Imidazolium Tetraalkoxycalix[4]arene Derivatives

Volume: 13 Issue: 1

Author(s): Iryna O. Melezhyk, Roman V. Rodik, Nataliia V. Iavorska, Andrey S. Klymchenko, Yves Mely, Victoriia V. Shepelevych, Larisa M. Skivka and Vitaly I. Kalchenko

Affiliation:

Keywords: Antibacterial, biofilm, calixarene, QAS, structure-activity relationship.

Abstract: The antibacterial and antibiofilm activities of several amphiphillic tetracationic calixarenes with different functional groups were evaluated. Our results demonstrate the clear dependence of antibacterial activity from the alkyl chain length on the lower rim of calixarene. Tetrapropoxycalixarenes have 10-50 times higher antibacterial activity than tetraoctyl calixarenes with same cationic residues on the upper rim. At the same time, one of the tetrapropoxycalixarenes shows high inhibitory activity against Staphylococcus aureus biofilms. Therefore, the alkyl chain length is an important characteristic that can be used for further antibacterial agent design.

Cite this article as:

O. Melezhyk Iryna, V. Rodik Roman, V. Iavorska Nataliia, S. Klymchenko Andrey, Mely Yves, V. Shepelevych Victoriia, M. Skivka Larisa and I. Kalchenko Vitaly, Antibacterial Properties of Tetraalkylammonium and Imidazolium Tetraalkoxycalix[4]arene Derivatives, Anti-Infective Agents 2015; 13 (1) . https://dx.doi.org/10.2174/2211352513666150327002110