摘要
阿尔茨海默氏病(AD)是最常见的痴呆症,在老年人中以进行性记忆和认知功能缺失为特征。除了神经元的损伤,老年斑和神经原纤维缠结是AD患者大脑病变中的最大特征。越来越多的证据表明,氧化应激诱导的损伤可能在AD发病的起始和进程中发挥重要作用。产生和抑制氧自由基的失衡导致氧化还原损伤。这些活性氧增加β-淀粉样蛋白和微管相关蛋白高度磷酸化的形成和聚集,反之亦然。目前,还没有治疗该病的有效治法。然而,抗氧化剂的品种繁多,为延迟AD发生或者帮助AD患者改善症状等方面带来希望。本文将总结氧化应激在AD发病机理中的作用和AD的常用抗氧化剂治疗方法。
关键词: 阿尔茨海默氏症;抗氧化剂;氧化应激。
Current Alzheimer Research
Title:Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease
Volume: 12 Issue: 4
Author(s): Ahmed E. Abdel Moneim
Affiliation:
关键词: 阿尔茨海默氏症;抗氧化剂;氧化应激。
摘要: Alzheimer's disease (AD) is the most common form of dementia characterized by progressive loss of memory and other cognitive functions among older people. Senile plaques and neurofibrillary tangles are the most hallmarks lesions in the brain of AD in addition to neurons loss. Accumulating evidence has shown that oxidative stress–induced damage may play an important role in the initiation and progression of AD pathogenesis. Redox impairment occurs when there is an imbalance between the production and quenching of free radicals from oxygen species. These reactive oxygen species augment the formation and aggregation of amyloid-β and tau protein hyperphosphorylation and vice versa. Currently, there is no available treatments can modify the disease. However, wide varieties of antioxidants show promise to delay or prevent the symptoms of AD and may help in treating the disease. In this review, the role of oxidative stress in AD pathogenesis and the common used antioxidant therapies for AD will summarize.
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Cite this article as:
Ahmed E. Abdel Moneim , Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease, Current Alzheimer Research 2015; 12 (4) . https://dx.doi.org/10.2174/1567205012666150325182702
DOI https://dx.doi.org/10.2174/1567205012666150325182702 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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