Abstract
Sensing clinically relevant biomolecules is crucial for the detection and prevention of disease. Currently used detection methods tend to be expensive, time intensive, and specific for only one particular biomolecule of interest. Nanoparticle-based arrays using conjugated polymers have emerged as an analytical and potential clinical tool, allowing detection of a wide range of biomolecules using selective, not specific, sensor components. In this report, we highlight recent progress in nanoparticle - polymer sensor arrays in both the fundamental understanding of how the sensor arrays function as well as the detection of clinically relevant bacteria and cells.
Keywords: Biosensing, conjugated polymers, displacement assay, nanoparticles.
Graphical Abstract
Current Organic Chemistry
Title:Polymer – Nanoparticle Assemblies for Array Based Sensing
Volume: 19 Issue: 12
Author(s): Brian Creran, Uwe H.F. Bunz and Vincent M. Rotello
Affiliation:
Keywords: Biosensing, conjugated polymers, displacement assay, nanoparticles.
Abstract: Sensing clinically relevant biomolecules is crucial for the detection and prevention of disease. Currently used detection methods tend to be expensive, time intensive, and specific for only one particular biomolecule of interest. Nanoparticle-based arrays using conjugated polymers have emerged as an analytical and potential clinical tool, allowing detection of a wide range of biomolecules using selective, not specific, sensor components. In this report, we highlight recent progress in nanoparticle - polymer sensor arrays in both the fundamental understanding of how the sensor arrays function as well as the detection of clinically relevant bacteria and cells.
Export Options
About this article
Cite this article as:
Creran Brian, H.F. Bunz Uwe and M. Rotello Vincent, Polymer – Nanoparticle Assemblies for Array Based Sensing, Current Organic Chemistry 2015; 19 (12) . https://dx.doi.org/10.2174/1385272819666150318221301
DOI https://dx.doi.org/10.2174/1385272819666150318221301 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Repositioning the Old Fungicide Ciclopirox for New Medical Uses
Current Pharmaceutical Design A Role for the Inflammatory Mediators Cox-2 and Metalloproteinases in Cancer Stemness
Anti-Cancer Agents in Medicinal Chemistry Radiopharmaceutical Chemistry with Iodine-124: A Non-Standard Radiohalogen for Positron Emission Tomography
Medicinal Chemistry Protein Tyrosine Signaling and its Potential Therapeutic Implications in Carcinogenesis
Current Pharmaceutical Design Applications of Nanosystems to Anticancer Drug Therapy (Part II. Dendrimers, Micelles, Lipid-based Nanosystems)
Recent Patents on Anti-Cancer Drug Discovery Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases
Current Pharmaceutical Design Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer
Combinatorial Chemistry & High Throughput Screening Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Anticancer Activity Assessment and DNA Binding Properties of Two Binuclear Platinum (II) Complexes using Spectroscopic and Molecular Simulation Approaches
Anti-Cancer Agents in Medicinal Chemistry Internalization and Intracellular Trafficking of Poly(propylene imine) Glycodendrimers with Maltose Shell in Melanoma Cells
Current Medicinal Chemistry Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer
Current Drug Research Reviews Engineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment
Current Medicinal Chemistry Biological Activities of Artemisinin Derivatives Beyond Malaria
Current Topics in Medicinal Chemistry Bone-Targeted Doxorubicin-Loaded Nanoparticles as a Tool for the Treatment of Skeletal Metastases
Current Cancer Drug Targets Breast Cancer Chemoprevention: Current Perspectives
Current Enzyme Inhibition Lymphatic Targeting of Nanosystems for Anticancer Drug Therapy
Current Pharmaceutical Design Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers
Medicinal Chemistry Ultrasound Contrast Imaging in Cancer –Technical Aspects and Prospects
Current Molecular Imaging (Discontinued) Natural Product Inhibitors of the Ubiquitin-Proteasome Pathway
Current Drug Targets Synthesis, DNA Binding Ability and Anticancer Activity of 2-heteroaryl Substituted Benzimidazoles Linked Pyrrolo[2,1-c][1,4]benzodiazepine Conjugates
Medicinal Chemistry