Abstract
The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the reaction makes it a valuable synthetic tool to prepare simple as well as densely functionalized and complex molecular scaffolds. This review is devoted to the recent evolution of the reaction, which considerably widens its product scope and synthetic potential. The main recent developments on the HWE reaction presented in this work comprise novel phosphonate reagents and sequential reactions involving the HWE olefination. Interesting applications, including access to challenging or complex synthetic targets, relevant organic compounds and natural products are also highlighted.
Keywords: Horner-Wadsworth-Emmons reaction, carbonyl olefinations, functionalized phosphonate reagents, functionalized olefins, one-pot reactions, tandem reactions.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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