基于秋水仙碱和抗淀粉样变性的家族性地中海热中生物制剂

Title:Biological Agents in Familial Mediterranean Fever Focusing on Colchicine Resistance and Amyloidosis

Volume: 22 Issue: 16

Author(s): Betul Sozeri and Ozgur Kasapcopur

Affiliation:

关键词: 秋水仙碱耐药，家族性地中海热，治疗

摘要: Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome. FMF is caused by mutations in the MEFV gene which encodes the pyrin protein. FMF is characterized by sporadic, paroxysmal attacks of fever and serosal inflammation, lasting 1-3 days. Patients may develop renal amyloidosis. Colchicine prevents attacks and renal amyloidosis.5% to 10% of the patients with FMF are resistant or intolerant to colchicine. Colchicine resistant patients may receive biological therapies. Anti-interleukin-1 drugs are the most important agents of biological treatments. In this review, colchicine resistance and treatment options will be evaluated.

Cite this article as:

Betul Sozeri and Ozgur Kasapcopur , Biological Agents in Familial Mediterranean Fever Focusing on Colchicine Resistance and Amyloidosis, Current Medicinal Chemistry 2015; 22 (16) . https://dx.doi.org/10.2174/0929867322666150311152300