DNA损伤修复是受损神经退行性疾病和精神疾病的共同特征

Title:Impaired DNA Damage Repair as a Common Feature of Neurodegenerative Diseases and Psychiatric Disorders

Volume: 15 Issue: 2

Author(s): H. Shiwaku and H. Okazawa

Affiliation:

关键词: 阿尔茨海默氏症，DNA损伤，亨廷顿氏症，小头畸型，精神分裂症。

摘要: Impaired DNA damage repair is a common pathological endophenotype of some types of neurodegenerative diseases, intellectual disabilities, and psychiatric diseases. Dysfunctional DNA repair and DNA damage, including DNA double-stranded breaks, are linked to transcriptional dysfunction and abnormal DNA methylation. Impaired DNA repair in neural stem cells leads to microcephaly or cerebellar ataxia. Furthermore, DNA repair defects and DNA damage in mature neurons lead to progressive cognitive impairment, which might be a common feature of Alzheimer's disease, Huntington’s disease, and other polyglutamine diseases. Oxidative DNA damage and altered DNA repair gene expression are observed in GABAergic neurons in schizophrenia. These findings indicate that impaired DNA repair is a common pathological endophenotype of neurological diseases, and that DNA damage might lead to diverse disease symptoms dependent on timing and the affected cell type.

Cite this article as:

H. Shiwaku and H. Okazawa , Impaired DNA Damage Repair as a Common Feature of Neurodegenerative Diseases and Psychiatric Disorders, Current Molecular Medicine 2015; 15 (2) . https://dx.doi.org/10.2174/1566524015666150303002556