摘要
疼痛由感觉歧视和消极情感组成。疼痛感觉组成的神经机制已被广泛研究。另一方面,疼痛的情感组成的神经机制仍有待调查。最近的行为研究揭示了大脑区域和神经机制参与了疼痛的情感组成。前扣带皮层和基底外侧杏仁核中谷氨酸能的传输在疼痛导致的厌恶中起着至关重要的作用。终纹床核腹侧和背外侧核的去甲肾上腺素和促肾上腺皮质激素的释放因子(CRF)分别在疼痛所致的厌恶中扮演了重要的角色。电生理学的研究表明,去甲肾上腺素和促皮质激素释放因子激活的II型BNST神经元,可以抑制BNST输出神经元。最近的一项组织化学研究显示,大多数脑腹侧背盖区BNST输出神经元是氨基丁酸能神经元,其优先使脑腹侧被盖区的氨基丁酸能神经元与突触联系。因此,活化的腹侧被盖区BNST输出神经元会增加多巴胺能神经元兴奋性,可能是通过抑制了多巴胺能神经元的输入,负调节氨基丁酸能神经元起作用的。疼痛引起BNST中的去甲肾上腺素和促肾上腺皮质激素释放因子释放,激活II型BNST神经元,从而抑制脑腹侧被盖区BNST输出神经元,降低对多巴胺能神经元的兴奋效应。最近光遗传学研究表明脑腹侧被盖区多巴胺能神经元的抑制足以引起位置厌恶。疼痛所致的位置厌恶可能是由于腹侧被盖区多巴胺能神经元的抑制所致,其通过BNST中疼痛的信息的处理起作用。
关键词: 终纹床核,抑制,多巴胺,情感,泛杏仁核结构,去甲肾上腺素,疼痛,腹侧被盖区
Current Molecular Medicine
Title:How Does Pain Induce Negative Emotion? Role of the Bed Nucleus of the Stria Terminalis in Pain-Induced Place Aversion
Volume: 15 Issue: 2
Author(s): M. Minami and S. Ide
Affiliation:
关键词: 终纹床核,抑制,多巴胺,情感,泛杏仁核结构,去甲肾上腺素,疼痛,腹侧被盖区
摘要: Pain consists of sensory-discriminative and negative-affective components. Neuronal mechanisms for the sensory component of pain have been investigated extensively. On the other hand, neuronal mechanisms for the affective component of pain remain to be investigated. Recent behavioral studies have revealed the brain regions and neuronal mechanisms involved in the affective component of pain. Glutamatergic transmission within the anterior cingulate cortex and basolateral amygdaloid nucleus plays a critical role in pain-induced aversion. Noradrenaline and corticotropin-releasing factor (CRF) within the ventral and dorsolateral parts of the bed nucleus of the stria terminalis (BNST), respectively, play important roles in paininduced aversion. Electrophysiological studies have revealed that both noradrenaline and CRF activate type II BNST neurons, which may inhibit the BNST output neurons. A recent histochemical study showed that most VTA-projecting BNST output neurons are GABAergic neurons, which preferentially make synaptic contact with VTA GABAergic neurons. Therefore, activation of VTA-projecting BNST output neurons should increase the neuronal excitability of VTA dopaminergic (DAergic) neurons through increased inhibitory input to VTA GABAergic neurons, which negatively regulate VTA DAergic neurons. Pain-induced release of noradrenaline and CRF within the BNST may activate type II BNST neurons, which could suppress VTA-projecting BNST output neurons, thereby attenuating the excitatory influence to the VTA DAergic neurons. Recent optogenetic studies suggest that the suppression of VTA DAergic neurons is sufficient to induce place aversion. Pain-induced place aversion may be due to the suppression of VTA DAergic neurons via the processing of nociceptive information within the BNST.
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M. Minami and S. Ide , How Does Pain Induce Negative Emotion? Role of the Bed Nucleus of the Stria Terminalis in Pain-Induced Place Aversion, Current Molecular Medicine 2015; 15 (2) . https://dx.doi.org/10.2174/1566524015666150303002336
DOI https://dx.doi.org/10.2174/1566524015666150303002336 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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