靶向纺锤体装配检查点治疗乳腺癌

Title:Targeting the Spindle Assembly Checkpoint for Breast Cancer Treatment

Volume: 15 Issue: 4

Author(s): Sandra Marques, Joana Fonseca, Patricia M.A. Silva and Hassan Bousbaa

Affiliation:

关键词: 非整倍性，抗有丝分裂，乳腺癌，基因表达，纺锤体装配检查点，靶向治疗。

摘要: Breast cancer is the most common malignancy in women worldwide and the second leading cause of cancer deaths after lung cancer. As in other malignancies, aneuploidy is a common feature of breast cancer and influences its behavior. Aneuploidy has been linked to inappropriate activity of the spindle assembly checkpoint (SAC), a surveillance mechanism that, in normal cells, prevents anaphase onset until correct alignment of all chromosomes at the metaphase is achieved. Interestingly, the widely used anti-microtubule drugs, vinca alkaloids and taxanes, kill cancer cells through chronic arrest in mitosis as a consequence of chronic SAC activation. Deregulated SAC has been reported in breast cancer in many reports and presents an attractive therapeutic strategy. We present here a review of the current knowledge on the SAC defects and the underlying molecular mechanisms in breast cancer, and discuss the potential of SAC components as targets for breast cancer therapies.

Cite this article as:

Sandra Marques, Joana Fonseca, Patricia M.A. Silva and Hassan Bousbaa , Targeting the Spindle Assembly Checkpoint for Breast Cancer Treatment, Current Cancer Drug Targets 2015; 15 (4) . https://dx.doi.org/10.2174/1568009615666150302130010