摘要
乳腺癌是全球女性中最常见的恶性肿瘤,是仅次于肺癌的第二大癌症导致的死亡。正如在其他恶性肿瘤中一样,非整倍性是乳腺癌的一个共性并影响其行为。非整倍性与纺锤体装配检查点 (SAC) 的不适当活动有关,SAC是在正常细胞中到达到中期染色体正确定位可防止后期发病的一个监控机制。有趣的是,广泛使用的抗微管药物、长春花碱和紫杉醇,通过作为慢性SAC活化的结果在有丝分裂中慢性阻滞来杀死癌细胞。解除对SAC的管制已在许多关于乳腺癌的报道中被报道,提出了一个有吸引力的治疗策略。我们在此综述了有关SAC缺点的现有知识和乳腺癌潜在分子机制,探讨了SAC作为乳腺癌治疗靶标的潜能。
关键词: 非整倍性,抗有丝分裂,乳腺癌,基因表达,纺锤体装配检查点,靶向治疗。
图形摘要
Current Cancer Drug Targets
Title:Targeting the Spindle Assembly Checkpoint for Breast Cancer Treatment
Volume: 15 Issue: 4
Author(s): Sandra Marques, Joana Fonseca, Patricia M.A. Silva and Hassan Bousbaa
Affiliation:
关键词: 非整倍性,抗有丝分裂,乳腺癌,基因表达,纺锤体装配检查点,靶向治疗。
摘要: Breast cancer is the most common malignancy in women worldwide and the second leading cause of cancer deaths after lung cancer. As in other malignancies, aneuploidy is a common feature of breast cancer and influences its behavior. Aneuploidy has been linked to inappropriate activity of the spindle assembly checkpoint (SAC), a surveillance mechanism that, in normal cells, prevents anaphase onset until correct alignment of all chromosomes at the metaphase is achieved. Interestingly, the widely used anti-microtubule drugs, vinca alkaloids and taxanes, kill cancer cells through chronic arrest in mitosis as a consequence of chronic SAC activation. Deregulated SAC has been reported in breast cancer in many reports and presents an attractive therapeutic strategy. We present here a review of the current knowledge on the SAC defects and the underlying molecular mechanisms in breast cancer, and discuss the potential of SAC components as targets for breast cancer therapies.
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Cite this article as:
Sandra Marques, Joana Fonseca, Patricia M.A. Silva and Hassan Bousbaa , Targeting the Spindle Assembly Checkpoint for Breast Cancer Treatment, Current Cancer Drug Targets 2015; 15 (4) . https://dx.doi.org/10.2174/1568009615666150302130010
DOI https://dx.doi.org/10.2174/1568009615666150302130010 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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