Necrosis Avidity of Organic Compounds: A Natural Phenomenon with Exploitable Theragnostic Potentials

Title:Necrosis Avidity of Organic Compounds: A Natural Phenomenon with Exploitable Theragnostic Potentials

Volume: 22 Issue: 15

Author(s): Marlein Miranda Cona, Raymond Oyen and Yicheng Ni

Affiliation:

Keywords: Cancer, cardiovascular diseases, diagnosis, necrosis, necrosis avid compounds, treatment.

Abstract: Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications in translational medicine. This article reviews the current concept of necrosis including definition, etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting agents and their potential applications in preclinical and clinical settings are also elaborated and discussed.

Cite this article as:

Cona Miranda Marlein, Oyen Raymond and Ni Yicheng, Necrosis Avidity of Organic Compounds: A Natural Phenomenon with Exploitable Theragnostic Potentials, Current Medicinal Chemistry 2015; 22 (15) . https://dx.doi.org/10.2174/0929867322666150227153550