Structural and Modeling Studies on ecto-5’-nucleotidase Aiding in Inhibitor Design

Title:Structural and Modeling Studies on ecto-5’-nucleotidase Aiding in Inhibitor Design

Volume: 15 Issue: 1

Author(s): Norbert Furtmann and Jurgen Bajorath

Affiliation:

Keywords: Catalytic mechanism, computational design, Ecto-5’-nucleotidase, inhibitors, virtual screening, x-ray crystallography.

Abstract: Ecto-5’-nucleotidase (e5NT) hydrolyzes extracellular nucleotides and contributes to purinergic signaling. e5NT is implicated in a variety of pathological states including immunological diseases and cancer and represents an emerging drug target. Herein, we review structural and computational studies that have helped to better understand ligand binding characteristics and mechanistic features of the enzyme and led to the identification of new classes of e5NT inhibitors.

Cite this article as:

Furtmann Norbert and Bajorath Jurgen, Structural and Modeling Studies on ecto-5’-nucleotidase Aiding in Inhibitor Design, Mini-Reviews in Medicinal Chemistry 2015; 15 (1) . https://dx.doi.org/10.2174/1389557515666150219112630