Abstract
The main aim of the current research is to achieve active targeting of antimicrobials in secondary urinary tract infections using the direction of renal blood flow. The objective is further extended to maintain a constant internal environment and to deliver an extended maintenance dose using Poly lactic acid (PLLA) electrospun nanofibers. The medicated nanofibers used to evaluate their physical characteristics and drug release behaviour. Therapeutic efficacy of the developed formulation was achieved by organ distribution, pharmacokinetic and challenge study. A major fraction of drug was recovered from the kidney after 32 hours results in a significant reduction in colony forming unit (CFU) count establish the therapeutic efficacy of developed formulation. Polyanionic nature of PLLA electrospun nanofibers assists as an excellent carrier for intravaginal delivery of antimicrobial in urinary tract infections.
Keywords: Electrospinning, fluconazole, nanofiber, vaginal candidiasis.
Graphical Abstract
Current Drug Delivery
Title:Development, Optimization and Evaluation of Electrospun Nanofibers: Tool for Targeted Vaginal Delivery of Antimicrobials Against Urinary Tract Infections
Volume: 13 Issue: 5
Author(s): Rajwinder Kaur, Tarun Garg, Amit K Goyal and Goutam Rath
Affiliation:
Keywords: Electrospinning, fluconazole, nanofiber, vaginal candidiasis.
Abstract: The main aim of the current research is to achieve active targeting of antimicrobials in secondary urinary tract infections using the direction of renal blood flow. The objective is further extended to maintain a constant internal environment and to deliver an extended maintenance dose using Poly lactic acid (PLLA) electrospun nanofibers. The medicated nanofibers used to evaluate their physical characteristics and drug release behaviour. Therapeutic efficacy of the developed formulation was achieved by organ distribution, pharmacokinetic and challenge study. A major fraction of drug was recovered from the kidney after 32 hours results in a significant reduction in colony forming unit (CFU) count establish the therapeutic efficacy of developed formulation. Polyanionic nature of PLLA electrospun nanofibers assists as an excellent carrier for intravaginal delivery of antimicrobial in urinary tract infections.
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Cite this article as:
Kaur Rajwinder, Garg Tarun, Goyal K Amit and Rath Goutam, Development, Optimization and Evaluation of Electrospun Nanofibers: Tool for Targeted Vaginal Delivery of Antimicrobials Against Urinary Tract Infections, Current Drug Delivery 2016; 13 (5) . https://dx.doi.org/10.2174/1567201812666150212123348
DOI https://dx.doi.org/10.2174/1567201812666150212123348 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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