摘要
乳腺癌干细胞 (BCSCs)是乳腺癌中的一种罕见细胞的异种亚群,显示出一个增强的肿瘤启动能力和潜在的疾病进展和治疗抵抗。 在减轻病人的死亡率的处境下,阐明它们的表型,生物和功能概要是一个主要的挑战。本综述,简要描述了癌症干细胞和肿瘤微环境是如何作用于肿瘤保护和肿瘤多样性,我们总结了近期关于乳腺癌干细胞分子信号的文献,这些干细胞既不定位于原发性肿瘤也不在乳腺癌患者的血液中循环。我们呈现了最近的关于特定干细胞和上皮细胞间质转型 表明乳腺癌干细胞亚群和强调它们的致病意义的数据。乳腺癌干细胞的分子特性促进了以BCSCs为靶向的新颖治疗方法的设计,目前正在进行临床评估。我们强调最近的关于乳腺癌干细胞靶向治疗策略的新颖的观点,该策略包括细胞信号通路的抑制、分化治疗、代谢的干扰和核苷酸、生物和纳米技术为基础的方法。通过乳腺癌干细胞直接疗法消除乳腺肿瘤细胞化疗和放疗的副作用,结合传统的治疗方法,会增加乳腺癌治疗的有效性,提高乳腺癌患者的临床治愈结果。
关键词: 乳腺癌,肿瘤干细胞,循环肿瘤细胞,上皮细胞间质转型,靶向肿瘤干细胞
图形摘要
Current Cancer Drug Targets
Title:Cancer Stem Cells in Solid and Liquid Tissues of Breast Cancer Patients: Characterization and Therapeutic Perspectives
Volume: 15 Issue: 3
Author(s): Rena Chiotaki, Hara Polioudaki and Panayiotis A. Theodoropoulos
Affiliation:
关键词: 乳腺癌,肿瘤干细胞,循环肿瘤细胞,上皮细胞间质转型,靶向肿瘤干细胞
摘要: Breast cancer stem cells (BCSCs) represent a heterogeneous subpopulation of rare cells within breast cancer tumors, displaying an enhanced tumor initiating capability and underlying disease progression and therapy resistance. Unraveling their phenotypic, biological and functional profile is a major challenge in the context of diminishing patient mortality. In this review, following a brief description on how cancer stem cells (CSCs) and their microenvironment contribute to tumor preservation and heterogeneity, we summarize the current literature regarding the molecular signature of BCSCs either localized in the primary tumor or circulating in the blood of breast cancer patients. We present recent data on specific stem and epithelial-to-mesenchymal transition (EMT) markers designating the BCSC subpopulation and underline their pathogenic significance. The molecular characterization of BCSCs has promoted the design of novel therapeutic approaches targeting the BCSC subpopulation which are currently being experimentally and clinically evaluated. We highlight recent advances on the development of novel BCSC-targeting therapeutic strategies including the inhibition of cell signaling pathways, differentiation therapy, metabolic interference and nucleotide-, bio- and nano-technology based approaches. Eliminating the chemo- and radio-resistance properties of breast cancer tumor cells via BCSC-directed therapies, combined to conventional therapeutic approaches, will augment the effectiveness of breast cancer treatment and improve the clinical outcome of breast cancer patients.
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Cite this article as:
Rena Chiotaki, Hara Polioudaki and Panayiotis A. Theodoropoulos , Cancer Stem Cells in Solid and Liquid Tissues of Breast Cancer Patients: Characterization and Therapeutic Perspectives, Current Cancer Drug Targets 2015; 15 (3) . https://dx.doi.org/10.2174/1568009615666150211102503
DOI https://dx.doi.org/10.2174/1568009615666150211102503 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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