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Current Green Chemistry

Editor-in-Chief

ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

Synthesis of (S)-(+)-2-(N-benzylamino)butan-1-ol from its Schiff Base by Catalytic Hydrogenation over Palladium

Author(s): Laszlo Hegedus, Sandor Miskolczi, Gyorgy Bansaghi, Edit Szekely and Ferenc Faigl

Volume 2, Issue 3, 2015

Page: [312 - 318] Pages: 7

DOI: 10.2174/2213346102666150211001310

Price: $65

Abstract

A chiral 1,2-amino alcohol derivative, (S)-(+)-2-(N-benzylamino)butan-1-ol (BAB), was synthesized from its Schiff base by catalytic hydrogenation over palladium on carbon, in various solvents (toluene, methanol, hexane, dichloromethane, tetrahydrofuran, ethyl acetate), under mild conditions (room temperature, atmospheric pressure). Preparation of the Schiff base was also optimized. This compound is a resolving agent for preparing optically active, practically important cyclopropanecarboxylic acids.

Keywords: Heterogeneous catalysis, hydrogenation, palladium, supported metal catalyst.

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