摘要
低氧和缺血在脑血管疾病例如中风的发病机理中起到了重要作用。然而,在临床设计中对抗低氧或缺血性损伤的保护方案非常有限。这加强了我们对提高缺氧和缺血瀑布认识及探索治疗低氧/缺血损伤新方法方面的需求。近期研究确定了microRNAs在调节低氧/缺血状况基因表达方面的重要作用。这些非编码RNA的19-24核苷酸分子在基因表达中起抑制调节的作用,主要通过把mRNA作为靶点和促进RNA降解或平移表达。在低氧/缺血状况下,他们大脑过其它器官分别调节。以microRNA表达/活性未靶点为干预低氧和缺血损伤提供了一种潜在有效的方法。本综述中,我们突出了我们近期研究的总结更新,它深入了 microRNA诱导的细胞和分子调节在低氧和/或缺血应激反应中的作用机制。
关键词: 大脑,心,低氧,缺血,肾,微小核糖核酸
Current Medicinal Chemistry
Title:Effects of Hypoxia and Ischemia on MicroRNAs in the Brain
Volume: 22 Issue: 10
Author(s): Yilin Yang, Harleen K Sandhu, Feng Zhi, Fei Hua, Min Wu and Ying Xia
Affiliation:
关键词: 大脑,心,低氧,缺血,肾,微小核糖核酸
摘要: Hypoxia and ischemia play a major role in the pathogenesis of cerebrovascular diseases such as stroke. However, the protective strategies against hypoxic and ischemic insults are very limited in clinical settings. This has reinforced the need to improve our understanding of the hypoxic and ischemic cascades and explore novel solutions of hypoxic/ ischemic injury. Recent research has identified the crucial role of microRNAs in regulation of gene expression under hypoxic/ischemic conditions. These 19-24 ribonucleotide non-coding RNA molecules function as inhibitory modulators of gene expression, by targeting mRNAs and promoting either RNA degradation or translational repression. They are differentially regulated in the brain as well as other organs under hypoxic and ischemic conditions. Targeting microRNA expression/activity offers a potentially effective way to intervene against hypoxic and ischemic injury. In this review, we highlight recent updates with summary of our recent work, which provides an insight into the roles and mechanisms of microRNA-induced regulation of cellular and molecular processes in response to hypoxic and/or ischemic stress.
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Cite this article as:
Yilin Yang, Harleen K Sandhu, Feng Zhi, Fei Hua, Min Wu and Ying Xia , Effects of Hypoxia and Ischemia on MicroRNAs in the Brain, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150209154755
DOI https://dx.doi.org/10.2174/0929867322666150209154755 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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