摘要
在肿瘤分子生物学最新进展使得癌症靶向治疗有了并行和前所未有的进展。相比传统化疗治疗癌症,有针对性治疗可以提供更高的疗效和较低的毒性。然而,与传统的化疗相比,分子靶向癌症治疗耐药性也面临着挑战。肿瘤的多种机制是化疗耐药性产生的关键原因,这些机制包括射流转运蛋白的超表达、体内变化的药物靶点、凋亡异常、一系列的药代动力学问题。纳米技术为基础的方法在克服耐药性癌症治疗中被证明是有效的。结合靶向疗法与纳米技术的方法是克服靶向治疗癌症治疗耐药性的一种很有前途的战略。本文探讨了针对癌症的耐药机制,讨论纳米技术方法在克服耐药性研究的进展。
关键词: 抗药性,纳米技术,癌症靶向治疗
Current Medicinal Chemistry
Title:Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance
Volume: 22 Issue: 11
Author(s): Yan Gao, Jacson K. Shen, Lara Milane, Francis J. Hornicek, Mansoor M. Amiji and Zhenfeng Duan
Affiliation:
关键词: 抗药性,纳米技术,癌症靶向治疗
摘要: Recent advances in cancer molecular biology have resulted in parallel and unprecedented progress in the development of targeted cancer therapy. Targeted therapy can provide higher efficacy and lower toxicity than conventional chemotherapy for cancer. However, like traditional chemotherapy, molecularly targeted cancer therapy also faces the challenge of drug resistance. Multiple mechanisms are responsible for chemotherapy resistance in tumors, including over-expression of efflux transporters, somatic alterations of drug targets, deregulation of apoptosis, and numerous pharmacokinetic issues. Nanotechnology based approaches are proving to be efficacious in overcoming drug resistance in cancer. Combination of targeted therapies with nanotechnology approaches is a promising strategy to overcome targeted therapy drug resistance in cancer treatment. This review discusses the mechanisms of targeted drug resistance in cancer and discusses nanotechnology approaches to circumvent this resistance.
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Yan Gao, Jacson K. Shen, Lara Milane, Francis J. Hornicek, Mansoor M. Amiji and Zhenfeng Duan , Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance, Current Medicinal Chemistry 2015; 22 (11) . https://dx.doi.org/10.2174/0929867322666150209151851
DOI https://dx.doi.org/10.2174/0929867322666150209151851 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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