摘要
癌症病人需要更好的抗癌药物。在这些药物的研发中,药物化学发挥着至关重要的作用。一个有效药物的发现过程,化学家需要使用可靠的筛选方法来合成潜在的抗癌剂。这些方法不仅要检测出具有最高治疗潜力的化合物,也应该预测这种潜力是否可能会引起不良反应。不幸的是,当前的策略评估—体外抗癌活性无法可靠地做到这一点。本文分析这些策略并描述了另一种筛查方法。它是基于建立合适的实验条件来检测化合物,改善药物细胞毒性的选择性而于癌症治疗。这种以患者为中心的策略更容易测试,而且可以帮助药物化学家、其他参与研究人员发现抗癌药物,使得评估体外抗癌活性更可靠。
关键词: 抗癌活性,癌症,细胞毒活性,新药研发,筛选,选择性
Current Medicinal Chemistry
Title:A Simple and Reliable Approach for Assessing Anticancer Activity In Vitro
Volume: 22 Issue: 11
Author(s): Miguel Lopez-Lazaro
Affiliation:
关键词: 抗癌活性,癌症,细胞毒活性,新药研发,筛选,选择性
摘要: Cancer patients need better anticancer drugs, and medicinal chemistry can play a critical role in the discovery of these drugs. For an efficient drug discovery process, chemists working on the synthesis of potential anticancer agents need to use reliable screening methods. These methods should not only detect the compounds with the highest therapeutic potential, but should also predict whether such potential is high enough to deserve additional attention. Unfortunately, the current strategies for assessing anticancer activity in vitro are unable to do this reliably. This review article analyzes these strategies and describes an alternative screening approach. It is based on establishing suitable experimental conditions to detect compounds that improve the selective cytotoxicity of the drugs used in cancer therapy. This patient-oriented approach is easy to implement and may help medicinal chemists, and other researchers involved in cancer drug discovery, assess in vitro anticancer activity more reliably.
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Cite this article as:
Miguel Lopez-Lazaro , A Simple and Reliable Approach for Assessing Anticancer Activity In Vitro, Current Medicinal Chemistry 2015; 22 (11) . https://dx.doi.org/10.2174/0929867322666150209150639
DOI https://dx.doi.org/10.2174/0929867322666150209150639 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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