摘要
在不同的研究中对AD抑郁的患病率评估差异较大,一个可靠的研究结果对进一步的干预至关重要。为了确定AD病人抑郁的患病率,我们做了一个系统性综述和meta分析。我们检索PubMed和 Embase数据库,然后对其进行数据提取、质量评估、患病率估测和亚组分析。 本综述中包括63项研究。依照重性抑郁的DSM标准和针对痴呆的特定标准,抑郁的患病率分别为12.7% (CI, 8.8-17.8)和 42% (CI, 38-45) 。通过案例标识的层次亚组分析表明,参照DSM标准和特定标准,基于人群研究的患病率分别为5% (CI: 2-15)和 35% (CI: 29-41) ,而那些单一来源的分别为17% (CI: 11-25) 和43% (CI: 37-49)。MMSE得分分层的亚组分析揭示依据DSM标准和特定标准,重度AD抑郁的患病率分别为8% (CI: 5-15)和 48% (CI: 41-54),而那些轻度AD的患病率分别为 14% (CI: 8-24) 和40% (CI: 32- 47)。总之,DSM标准下的抑郁患病率低于特定标准下的概率。忽略筛选工具,与单一来源研究的患病率相比,基于人群研究的评估值较低。根据特定标准,重度AD病人有较高的抑郁症患病率,而DSM标准却相反。因此,在评估抑郁症和进一步干预之前,应该考虑不同的设置和诊断途径。
关键词: 阿尔茨海默病,抑郁,流行病学,meta分析,普遍,系统综述
Current Alzheimer Research
Title:The Prevalence of Depression in Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Volume: 12 Issue: 2
Author(s): Song Chi, Chong Wang, Teng Jiang, Xi-Chen Zhu, Jin-Tai Yu and Lan Tan
Affiliation:
关键词: 阿尔茨海默病,抑郁,流行病学,meta分析,普遍,系统综述
摘要: Prevalence estimates of depression in AD vary greatly across studies, and a reliable result is crucial for further interventions. A systematic review and meta-analysis was conducted to identify the prevalence of depression in AD patients. We searched PubMed and Embase, followed by data extraction, quality assessment, prevalence estimates and subgroup analyses. A total of 63 studies were included in the review. The prevalences of depression were 12.7% (CI, 8.8-17.8) and 42% (CI, 38-45) according to the DSM criteria for major depression and the specific criteria for dementia respectively. Subgroup analyses stratified by case identification showed that the prevalences of population-based stud ies were 5% (CI: 2-15) and 35% (CI: 29-41) according to the DSM criteria and the specific criteria respectively, while those of single source were 17% (CI: 11-25) and 43% (CI: 37-49). Subgroup analyses stratified by MMSE score revealed that the prevalences of severe AD were 8% (CI: 5-15) and 48% (CI: 41-54) according to the DSM criteria and the specific criteria respectively, while those of mild AD were 14% (CI: 8-24) and 40% (CI: 32- 47). In conclusion, the prevalence of depression according to the DSM criteria was lower than that of the specific criteria. Prevalence estimates conducted in population-based studies were lower compared with those in single-source studies irrespective of the screening tools. Patients with severe AD tended to have higher prevalence of depression according to the specific criteria, while the trend was opposite according to the DSM criteria. Thus, different settings and diagnostic approaches should be taken into account before estimates of depression and further interventions.
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Cite this article as:
Song Chi, Chong Wang, Teng Jiang, Xi-Chen Zhu, Jin-Tai Yu and Lan Tan , The Prevalence of Depression in Alzheimer’s Disease: A Systematic Review and Meta-Analysis, Current Alzheimer Research 2015; 12 (2) . https://dx.doi.org/10.2174/1567205012666150204124310
DOI https://dx.doi.org/10.2174/1567205012666150204124310 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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