The Integral Role of CD74 in Antigen Presentation, MIF Signal Transduction, and B Cell Survival and Homeostasis

Richard      Bucala; Idit      Shachar

doi:10.2174/1389557515666150203144111

Abstract

Molecules that link innate and adaptive immunity and regulate immune response in health and disease are now the focus of many studies. This review discusses CD74 and its ligand macrophage migration inhibitory factor (MIF), and their central position in linking these two components of the immune response by controlling survival of macrophages and B cells.

Keywords: Antigen presentation, CD74, invariant chain, MIF, MIF receptor, survival.

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Mini-Reviews in Medicinal Chemistry

Title: The Integral Role of CD74 in Antigen Presentation, MIF Signal Transduction, and B Cell Survival and Homeostasis

Volume: 14 Issue: 14

Author(s): Richard Bucala and Idit Shachar

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Keywords: Antigen presentation, CD74, invariant chain, MIF, MIF receptor, survival.

Abstract: Molecules that link innate and adaptive immunity and regulate immune response in health and disease are now the focus of many studies. This review discusses CD74 and its ligand macrophage migration inhibitory factor (MIF), and their central position in linking these two components of the immune response by controlling survival of macrophages and B cells.

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Bucala Richard and Shachar Idit, The Integral Role of CD74 in Antigen Presentation, MIF Signal Transduction, and B Cell Survival and Homeostasis, Mini-Reviews in Medicinal Chemistry 2014; 14 (14) . https://dx.doi.org/10.2174/1389557515666150203144111

DOI https://dx.doi.org/10.2174/1389557515666150203144111	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607