化学法，药物投递，荧光成像，多功能纳米探针，治疗。

Title:Multiscale Imaging of Nanoparticle Drug Delivery

Volume: 16 Issue: 6

Author(s): Lawrence W. Dobrucki, Dipanjan Pan and Andrew M. Smith

Affiliation:

关键词: 增强的通透性和保留，荧光，活体镜检，核磁共振成像，纳米材料，纳米药物，纳米技术，正电子发射体层摄影，量子点。

摘要: Nanoparticles have recently had a major impact on basic biosciences, the pharmaceutical industry, and preclinical and translational medicine by enabling targeted delivery of therapeutic cargo to cells and tissues. The capacity to specifically tailor the pharmacokinetics, biodistribution, and longterm fate of therapeutic molecules for specific diseases and to avoid off-target side effects is a tremendously promising capability of these materials. However targeting of nanoparticle therapies from systemic circulation is very inefficient, and our understanding of the fundamental processes dictating in vivo fate remains limited, making it challenging to determine how to optimally and rationally design these materials for maximum efficacy. Recently multi-modal, multi-scale imaging technologies have emerged that have helped to improve our insight into these processes. Theranostic imaging agents have provided real-time and quantitative readouts of drug distribution and therapeutic response, multimodal imaging platforms have allowed a multi-scale analysis of distribution from the levels of cells to tissues, and exciting applications in live-animal tissue microscopy have provided key insights at the cellular level. In this review, we describe how multiscale imaging has shaped our ability to optimize nanoparticle drugs and discuss future directions that are expected to further catalyze clinical translation.

Cite this article as:

Lawrence W. Dobrucki, Dipanjan Pan and Andrew M. Smith , Multiscale Imaging of Nanoparticle Drug Delivery, Current Drug Targets 2015; 16 (6) . https://dx.doi.org/10.2174/1389450116666150202163022