YY1 在肿瘤形成中的作用及其作为癌症治疗药物靶点的可能性

Title:The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies

Volume: 15 Issue: 2

Author(s): Jinming Shi, Aixin Hao, Qiang Zhang and Guangchao Sui

Affiliation:

关键词: 基因表达，基因，蛋白质相互作用，靶向治疗，肿瘤形成，转录因子阴阳-1。

摘要: Yin Yang 1 (YY1) is a multifunctional protein regulating both gene transcription and protein modifications. Recent studies reveal a proliferative role of YY1 in oncogenesis. Consistently, YY1 overexpression has been observed in various human malignancies and its levels correlate with poor prognoses of many types of cancers. In this review, we focus on the signaling pathways and regulatory proteins that YY1 modulates to promote tumor cell growth, proliferation, migration and metastasis. We also discuss the signals and molecules that regulate YY1 expression and function in cancer-related context. Based on the expression feature and regulatory activities in tumor cells, YY1 possesses a great potential as a biomarker for many cancers and can serve as a therapeutic target clinically to impede cancer development and progression or sensitize cancer cells to anticancer drugs.

Cite this article as:

Jinming Shi, Aixin Hao, Qiang Zhang and Guangchao Sui , The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies, Current Cancer Drug Targets 2015; 15 (2) . https://dx.doi.org/10.2174/1568009615666150131124200