Abstract
A green, efficient and operationally simple method for three-component synthesis of 1,2,3- trisubstituted pyrrole derivatives via an iodine-catalyzed tandem reaction has been developed, and a series of 1,2,3-trisubstituted pyrrole derivatives were synthesized from simple starting materials under neutral conditions, with good to excellent yields in short time. This method showcased the potential of great value as a mild, rapid, and general procedure for the synthesis of 1,2,3-trisubstituted pyrroles.
Keywords: 1, 2, 3-Trisubstituted pyrrole, iodocyclization, multicomponent reaction (MCR), tandem reaction.
Graphical Abstract
Letters in Organic Chemistry
Title:A Green and Efficient One-pot Synthesis of 1,2,3-Trisubstituted Pyrroles via Iodine-catalyzed Tandem Reaction
Volume: 12 Issue: 4
Author(s): Pengfei Xu, Kunzhu Huang, Dongsheng Cao and Wenbin Zeng
Affiliation:
Keywords: 1, 2, 3-Trisubstituted pyrrole, iodocyclization, multicomponent reaction (MCR), tandem reaction.
Abstract: A green, efficient and operationally simple method for three-component synthesis of 1,2,3- trisubstituted pyrrole derivatives via an iodine-catalyzed tandem reaction has been developed, and a series of 1,2,3-trisubstituted pyrrole derivatives were synthesized from simple starting materials under neutral conditions, with good to excellent yields in short time. This method showcased the potential of great value as a mild, rapid, and general procedure for the synthesis of 1,2,3-trisubstituted pyrroles.
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Cite this article as:
Xu Pengfei, Huang Kunzhu, Cao Dongsheng and Zeng Wenbin, A Green and Efficient One-pot Synthesis of 1,2,3-Trisubstituted Pyrroles via Iodine-catalyzed Tandem Reaction, Letters in Organic Chemistry 2015; 12 (4) . https://dx.doi.org/10.2174/1570178612666150119232103
DOI https://dx.doi.org/10.2174/1570178612666150119232103 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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