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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Nanostructured Cubosomes as a Platform for Oral Drug Delivery

Author(s): Min Liu, Meiwan Chen, Ping Xu and Zhiwen Yang

Volume 16, Issue 4, 2015

Page: [313 - 321] Pages: 9

DOI: 10.2174/1389201016666150118134805

Price: $65

Abstract

Cubosomes are formed by amphiphilic molecules, with the bicontinuous contortions of inter-connecting hydrophilic and hydrophobic domains. The inner cubic-phase structure of cubosomes makes it an attractive drug-delivery system in pharmaceutical applications. This review mainly describes the potential applications of cubosomes as a drug delivery system for oral administration, highlights the mechanisms involved in the transcellular transport and digestive process, challenges involved in formulation development and evaluations of the in vivo and in vitro study. As pointed out throughout this review, a number of critical points on cubosome products need to be solved in order to attain practical applications.

Keywords: Cubosomes, in vitro, in vivo, oral delivery system.

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