Natural Compounds Used as Therapies Targeting to Amyotrophic Lateral Sclerosis

Title:Natural Compounds Used as Therapies Targeting to Amyotrophic Lateral Sclerosis

Volume: 16 Issue: 3

Author(s): Seyed F. Nabavi, Maria Daglia, Giuseppe D’Antona, Eduardo Sobarzo-Sanchez, Zeliha S. Talas and Seyed M. Nabavi

Affiliation:

Keywords: Amyotrophic lateral sclerosis, natural substances, polyphenol, oxidative stress.

Abstract: Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease that occurs throughout the world with no racial, ethnic or socioeconomic boundaries. Despite its high morbidity and mortality, there are limited medications available for ALS that may increase survival in patients with amyotrophic lateral sclerosis by approximately 2-3 months. Inasmuch as negative effects of riluzole on muscle atrophy and wasting, weakness, muscle spasticity, dysarthria, dysphagia, and overall patient quality of life and its different adverse effects, much attention has been paid to natural products and herbal medicines. Overall scientific reports indicate that natural products have beneficial effects on patients with ALS low side effects and multiple targets. In the present paper, we review the scientific reports on beneficial role of natural polyphenolic compounds in treatment of ALS.

Cite this article as:

Nabavi F. Seyed, Daglia Maria, D’Antona Giuseppe, Sobarzo-Sanchez Eduardo, Talas S. Zeliha and Nabavi M. Seyed, Natural Compounds Used as Therapies Targeting to Amyotrophic Lateral Sclerosis, Current Pharmaceutical Biotechnology 2015; 16 (3) . https://dx.doi.org/10.2174/1389201016666150118132224