Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents

Title:Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents

Volume: 3 Issue: 1

Author(s): Ashok Sharma, Rajdeep Chowdhury, Subhra Dash, Badvel Pallavi and Paritosh Shukla

Affiliation:

Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.

Abstract: A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency.

Cite this article as:

Sharma Ashok, Chowdhury Rajdeep, Dash Subhra, Pallavi Badvel and Shukla Paritosh, Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents, Current Microwave Chemistry 2016; 3 (1) . https://dx.doi.org/10.2174/2213335602666150116233238