摘要
尽管在药理模式取得进展,治疗眼科疾病仍然是不便捷的,创伤性的、昂贵和最终的视觉能力也常常是非常差的。多肽,作为一个蛋白质的片段,能够适当的模拟蛋白质结合因而可以作为治疗药物。化学修饰和生物工程技术被经常采用以提高多肽的效力和稳定性,因而能够增加它们的药物能力。细胞穿透多肽(CPPS),以能够穿透血清膜为特征,是著名的血障碍透过剂。他们是好的候选试剂用于携带药物穿过视觉障碍。治疗性的多肽和CPP之间是相互互补的。一旦结合,它们可能形成一个最佳的配方用于眼部的局部给药,能够发挥药效和灵活性。随后无损伤的投递和经济成本能够实现早期干预、早期治疗和长期治疗以阻止慢性的不可逆视觉失去。本文的目的在于:a)总结最近治疗性多肽,抗血管生成和抗炎作用,通过体内的动物实验来验证;b)讨论治疗性多肽的发现策略;c)展示当前视觉性治疗多肽的投递策略;d)介绍通过眼表面给药投递药物至眼部空间的CCPs。
关键词: 抗血管生成,抗炎,细胞穿透多肽,视觉药物投递,多肽设计,灵巧药物投递,治疗性多肽。
Current Medicinal Chemistry
Title:A Promising Future for Peptides in Ophthalmology: Work Effectively and Smartly
Volume: 22 Issue: 8
Author(s): Q. Sun and X. Xu
Affiliation:
关键词: 抗血管生成,抗炎,细胞穿透多肽,视觉药物投递,多肽设计,灵巧药物投递,治疗性多肽。
摘要: Despite progress in pharmacological modalities, treatments for ocular diseases are inconvenient, traumatic, costly and often end in poor final visual results. Peptides, considered as protein fragments, can adequately mimic protein binding and thus are used as therapeutic agents. Chemical modifications and bioengineering techniques are being frequently introduced to improve efficacy and stability of peptides, thereby improving their druggability. Cell-penetrating peptides (CPPs), peptides characterized by penetrating plasma membrane, are famous barrier- passers. They are good candidates for carrying drugs through ocular barriers. Therapeutic peptide and CPP perfectly complement each other. Once united, they may form an optimal formula for ocular topical administration, which can work both effectively and smartly. The consequent noninvasive delivery and economical cost would actualize prophylactic intervention, early treatment and long-term therapy to avoid chronic irreversible vision loss. The aim of the current review is a) to summarize recent therapeutic peptides, both anti-angiogenic and anti-inflammation, evidenced by animal experiments in vivo; b) to discuss the discovery strategies for therapeutic peptide; c) to present current delivery strategies for ophthalmic therapeutic peptide; and d) to introduce CPPs which are capable to deliver cargos to intraocular space via ocular surface administration.
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Cite this article as:
Q. Sun and X. Xu , A Promising Future for Peptides in Ophthalmology: Work Effectively and Smartly, Current Medicinal Chemistry 2015; 22 (8) . https://dx.doi.org/10.2174/0929867322666150114163308
DOI https://dx.doi.org/10.2174/0929867322666150114163308 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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