摘要
目前,中风研究者正在加速开发使大脑免受局部缺血诱导损伤的神经保护策略。目前为止,在动物实验中有成功希望的神经保护药物应经在临床试验中失败。因为缺血性中风的病理是利用多种通路导致的细胞损伤,所以神经保护剂的联合用药,通过干预多种作用机制,也许比单独用药能够显示更好的效果。本文中,我们考虑采用常压氧(NBO)和乙醇的联合疗法。研究表明NBO疗法可以改善组织氧合,因此在中风初期及早执行可以减少缺血损伤的范围和减速组织坏死的发展。研究也已经证明怎么调节乙醇的水平使其不仅可以减少中风的风险,而且减少缺血后遗症。本文综述了中风治疗的情况下,NBO和乙醇疗法的历史、他们的作用机制、关键临床试验的结果及他们作为联合疗法的使用原理。
关键词: 血脑屏障,联合治疗,乙醇,缺血,神经保护,正常气压氧疗法,氧化应激,再灌注,中风
Current Medicinal Chemistry
Title:Neuroprotective Mechanisms of Oxygen and Ethanol: A Potential Combination Therapy in Stroke
Volume: 22 Issue: 10
Author(s): Sweena Parmar, Shannon Moore-Langston, Vance Fredrickson, Jung-Min Kim, Radhika Rastogi, Omar Elmadoun and Yuchuan Ding
Affiliation:
关键词: 血脑屏障,联合治疗,乙醇,缺血,神经保护,正常气压氧疗法,氧化应激,再灌注,中风
摘要: Currently, stroke researchers are racing to develop neuroprotective strategies that shield the brain from ischemia-induced injury. To date, neuroprotective agents that have shown promise in animal studies have failed in clinical trials. Since the pathophysiology of ischemic stroke exploits numerous pathways leading to cellular injury, a combination of neuroprotective agents may offer substantially better results than a single agent alone - by intervening in multiple mechanisms. In this paper, we consider an approach using combination therapy with normobaric oxygen (NBO) and ethanol. Studies indicate that NBO therapy improves tissue oxygenation, thereby reducing the extent of hypoxic injury and decelerating the development of tissue necrosis when administered early after stroke onset. Studies have also demonstrated that low to moderate levels of ethanol not only decrease the risk of stroke, but also reduce post-ischemic sequelae. This article reviews the history of NBO and ethanol therapies, their mechanisms of action, the results of key clinical trials, and the rationale for their use as a combination therapy in the context of stroke treatment.
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Sweena Parmar, Shannon Moore-Langston, Vance Fredrickson, Jung-Min Kim, Radhika Rastogi, Omar Elmadoun and Yuchuan Ding , Neuroprotective Mechanisms of Oxygen and Ethanol: A Potential Combination Therapy in Stroke, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150114152945
DOI https://dx.doi.org/10.2174/0929867322666150114152945 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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