摘要
血小板在免疫反应中起着非常重要的作用。血小板活性的受损可通过P-选择素,CD40-CD40L,和其他系统影响细胞粒、巨噬细胞、内皮细胞导致持续的粘膜炎症。药理学调节血小板活性可能降低血栓栓塞并限制血小板与内皮细胞及免疫细胞的相互作用,从而减弱了免疫反应。在本综述中,我们专注于血小板在炎性肠病病理生理活性,并讨论当前基于抗血小板治疗方法在胃肠道炎症中相关研究的可行性。最后,我们提出了一个展望,新的抗血小板药剂正在研发中。
关键词: 抗血小板药物,炎性肠病,血小板,血栓。
Current Drug Targets
Title:Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases
Volume: 16 Issue: 3
Author(s): Chunqiu Chen, Yongyu Li, Zhen Yu, Zhanju Liu, Yanhong Shi, Urszula Lewandowska and Marta Sobczak, Jakub Fichna and Martin Kreis
Affiliation:
关键词: 抗血小板药物,炎性肠病,血小板,血栓。
摘要: Platelets play a crucial role in immune responses. Impaired platelet activation may cause persistent mucosal inflammation through P-selectin, CD40-CD40L and other systems influencing granulocytes, macrophages or endothelial cells. Pharmacological regulation of platelet activation may reduce thromboembolism and limit the interaction of platelets with endothelial and inflammatory cells, in turn weakening the inflammatory responses. In this review we focus on pathophysiological activities of platelets in inflammatory bowel diseases and discuss the studies on currently available anti-platelet therapies in the treatment of gastrointestinal inflammation. Finally, we provide a prospective view to new anti-platelet agents currently under development.
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Cite this article as:
Chunqiu Chen, Yongyu Li, Zhen Yu, Zhanju Liu, Yanhong Shi, Urszula Lewandowska and Marta Sobczak, Jakub Fichna and Martin Kreis , Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases, Current Drug Targets 2015; 16 (3) . https://dx.doi.org/10.2174/1389450116666150113122229
DOI https://dx.doi.org/10.2174/1389450116666150113122229 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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